Clin Pediatr Hematol Oncol.  2009 Oct;16(2):145-150.

A Case of Chronic Active Epstein-Barr Virus Infection Progressed to Peripheral T-cell Lymphoma of Lung

• Yeon GM
• Kwon KA
• Kwak JW
• Park SS
• Park JH
• Lim YT

Abstract

Chronic active Epstein-Barr virus (EBV) infection (CAEBV) is a nonfamilial syndrome that shows a specific immunodeficiency for EBV. The primary features of CAEBV are recurrent or chronic infectious mononucleosis-like symptoms, such as prolonged fever, hepatosplenomegaly, persistent hepatitis and extensive lymphadenopathy for > or =3 months. The chronic illness cannot be explained by other known disease processes at diagnosis, and there is no underlying immunological identifiable abnormalities. Patients with CAEBV have unusual pattern of anti-EBV antibodies with high antivirus-capsid-antigen (anti-VCA) and anti-early antigen (anti-EA), and/or detection of high EBV genome levels in the affected tissues, including peripheral blood. CAEBV often results in life-threatening complications and 18% of those is malignant lymphoma, but malignant lymphoma of lung is very rare. We present a case of CAEBV that progressed to peripheral T-cell lymphoma of lung in a 10-year-old boy.

Keyword

Chronic active Epstein-Barr virus infection; Epstein-Barr virus; Peripheral T-cell lymphoma; Lung

MeSH Terms

Antibodies
Child
Chronic Disease
Fever
Genome
Hepatitis
Herpesvirus 4, Human
Humans
Lung
Lymphatic Diseases
Lymphoma
Lymphoma, T-Cell, Peripheral
Antibodies