Ann Dermatol.  1998 Apr;10(2):116-122. 10.5021/ad.1998.10.2.116.

Two Cases of the Angioimmunoblastic Lymphadenopathy Type of Peripheral T - cell Lymphoma : Different Clinical Courses According to Positivity to Epstein-Barr Virus

• Kim JW
• Nam SH
• Kim KJ
• Kim CM
• Lee CJ

• KMID: 2359806
• DOI: http://doi.org/10.5021/ad.1998.10.2.116

Abstract

Peripheral T-cel1 lymphoma(PTCL) encompasses histopathologically and clinically various spectra of cutaneous T-cell lymphoma(CTCL). In this report, we describe two cases of PTCL showing diRerent clinical courses according to EBV(Epstein-Barr virus) positivity. The chnical course of case 1 with EBV-associated PTCL was rapidby fatal and refractory to intensive chcmotherapy. However, in case 2, EBV genomes were not found in her lesional tissues and she showed an indolent clinical course withoaat systemic symptoms. Accordingly, serological and immunohistochemical investigations for EBV might be mandatory in cutaneous PTCL to evaluate clinical prognosis.

Keyword

Peripheral T-cell lymphoma; EBV

MeSH Terms

Genome
Herpesvirus 4, Human*
Immunoblastic Lymphadenopathy*
Lymphoma*
Lymphoma, T-Cell, Peripheral
Prognosis
T-Lymphocytes