Korean J Hematol.  2008 Sep;43(3):174-178. 10.5045/kjh.2008.43.3.174.

A Case of Epstein-Barr Virus-positive Diffuse, Large B-cell Lymphoma after Angioimmunoblastic T-cell Lymphoma

• Choi YH
• Kim HS
• Nam SB
• Kang HJ
• Na II
• Yang SH
• Ryoo BY

• KMID: 2252185
• DOI: http://doi.org/10.5045/kjh.2008.43.3.174

Abstract

Angioimmunoblastic T-cell lymphoma (AITL) is a systemic lymphoproliferative disorder that presents with profound immune dysfunction and immunodeficiency. As in many other immunodeficiencies, Epstein-Barr virus (EBV) associated B-cell lymphoid proliferation can occur in AITL but few cases of EBV-positive B-cell lymphoma have been reported in patients with preexisting AITL. We report a case of AITL in which EBV-positive diffuse large B-cell lymphoma (DLBCL) developed 13 months after the initial diagnosis of AITL. Although the exact mechanisms remain unclear, Epstein-Barr virus may have played a role in the pathogenesis of the secondary DLBCL

Keyword

Angioimmunoblastic T-cell lymphoma; Diffuse large B-cell lymphoma; Epstein-Barr virus

MeSH Terms

B-Lymphocytes
Herpesvirus 4, Human
Humans
Lymphoma, B-Cell
Lymphoma, T-Cell
Lymphoproliferative Disorders
T-Lymphocytes