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Clinicopathologic characterization of cervical metastasis from an unknown primary tumor: a multicenter study in Korea

Lee M, Jo U, Song JS, Lee YS, Woo CG, Kim DH, Kim JY, Yoon SO, Cho KJ

Background: Research regarding cervical metastasis from an unknown primary tumor (CUP) according to human papillomavirus (HPV) and Epstein-Barr virus (EBV) status in Korea has been sporadic and small-scale. This study...
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A Case of Chronic Active Epstein-Barr Virus Infection of External Auditory Canal Mimicking Cellulitis or Malignancy

Lee JH, Kim M, Kwon DH, Kong TH

Epstein-Barr virus (EBV) is an extremely prevalent virus which infects over 90% of the global population at some point in their lifetime. Chronic active EBV infection (CAEBV) is a disease...
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Comprehensive Analysis of Epstein-Barr Virus LMP2A-Specific CD8+ and CD4+ T Cell Responses Restricted to Each HLA Class I and II Allotype Within an Individual

Jo HA, Hyun SJ, Hyun YS, Lee YH, Kim SM, Baek IC, Sohn HJ, Kim TG

Latent membrane protein 2A (LMP2A), a latent Ag commonly expressed in Epstein-Barr virus (EBV)-infected host cells, is a target for adoptive T cell therapy in EBV-associated malignancies. To define whether...
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Unsuspected systemic Epstein-Barr virus–positive T-cell lymphoma of childhood diagnosed at autopsy in a potential homicide case

Robbins DJ, Ranheim EA, Kallan JE

Systemic Epstein-Barr virus (EBV)–positive T-cell lymphoma of childhood (SETLC) is a rare, rapidly progressive, and often fatal disease of children and young adults characterized by monoclonal expansion of EBV-positive T...
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Prognostic Perspectives of STING and PD-L1 Expression and Correlation with the Prognosis of Epstein-Barr Virus-Associated Gastric Cancers

Sun Q, Fu Y, Chen X, Li L, Wu H, Liu Y, Xu H, Zhou G, Fan X, Xia H

Background/Aims: Epstein-Barr virus-associated gastric cancers (EBVaGCs) have unique molecular and clinicopathological characteristics. The cyclic GMP-AMP synthase-stimulator of interferon genes (STING) pathway is recently recognized as the critical innate immunity against...
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EBV Associated Lymphomatoid Granulomatosis in 18-Year-Old Male: A Case Report

Jung ES, Bae EY, Roh EJ, Chung EH, You SK, Kim JM, Kim M, Lim YJ

Lymphomatoid granulomatosis (LYG) is an Epstein-Barr virus (EBV)-associated lymphoproliferative disease. It is considered a rare entity in pediatric patients. An adolescent male with lobar consolidation suspected of having pneumonia was...
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Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis Resembling Recurrent Follicular Lymphoma: A Case Report

Park CH, Choi YB

Epstein-Barr virus (EBV)-associated lymphoproliferative diseases represent various clinical manifestations. EBV-associated hemophagocytic lymphohistiocytosis (HLH) and lymphoma are difficult to distinguish due to overlapping characteristics between these two diseases. Here, we present...
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Performance Evaluation of the ELITe InGenius System for Detecting Cytomegalovirus, EpsteinBarr Virus, and BK Virus Infections

Woo KS, Han JY

Background: The ELITe-MGB Kit (ELITech Group, Italy) is a qualitative and quantitative nucleic acid amplification assay used for the detection and quantification of various viruses, especially in the clinical management...
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Epstein-Barr virus reactivation after COVID-19 vaccination in a young immunocompetent man: a case report

Herzum A, Trave I, D’Agostino F, Burlando M, Cozzani E, Parodi A

We present the case of a 24-year-old Caucasian man, who developed a scaly erythematous skin rash after the second dose of coronavirus disease 2019 (COVID-19) vaccination with Comirnaty (BNT162b2, BioNTech/Pfizer;...
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F‑18 FDG PET/CT in NK/T‑Cell Lymphoma that Progressed from Epstein‑Barr Virus‑Associated Hemophagocytic Lymphohistiocytosis

Kim I, An Y, Lee S, Yoon J

Hemophagocytic lymphohistiocytosis (HLH) is a syndrome involving an uncontrolled immune response with variable triggers. HLH is rare but highly fatal, even with proper treatment; therefore, early recognition and diagnosis are...
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A Boy with X-Linked Inhibitor of Apoptosis Protein (XIAP) Deficiency as the Initial Presentation of Pure Red Cell Aplasia

Sim SY, Choi HY, Han SB, Chung NG, Cho B, Kim M, Jeong DC

X-linked inhibitor of apoptosis protein (XIAP) deficiency is a rare immunodeficiency disorder. A 13-month-old boy was diagnosed with pure red cell aplasia (PRCA) and treated with steroid and cyclosporine. Bone...
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Epstein-Barr Virus-associated Mixed Lymphoepithelioma-like Carcinoma and Adenocarcinoma of the Gall Bladder: An Unusual Entity

Jain N, Goyal S, Sakhuja P, Saluja S

Schmincke described lymphoepithelioma as an undifferentiated carcinoma with abundant lymphoid stroma in the nasopharynx. Tumors with a similar histomorphology in extrapharyngeal areas have been referred to as lymphoepithelioma-like carcinoma (LELC)....
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A retrospective analysis of etiology and outcomes of hemophagocytic lymphohistiocytosis in children and adults

Kwak A, Jung N, Shim YJ, Kim HS, Lim HJ, Lee JM, Heo MH, Do YR

Background: Hemophagocytic lymphohistiocytosis (HLH) is a rare but severe, life-threatening inflammatory condition if untreated. We aimed to investigate the etiologies, outcomes, and risk factors for death in children and adults...
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Hydroa Vacciniforme-Like Lymphoproliferative Disorder in Korea: Prognostic Implication of Clinical Signs and Whole Blood Epstein-Barr Virus DNA

Oh SJ, Lee J, Park JH, Lee JH, Cho J, Ko YH, Lee D

Background: Hydroa vacciniforme-like lymphoproliferative disorder (HVLPD) is rare Epstein-Barr virus (EBV)-associated disease. The classic form of HVLPD is a self-resolving disease, whereas the systemic form can progress to malignant lymphoma,...
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EBV-Associated Lymphoproliferative Disorders

Ko YH

Epstein–Barr virus (EBV) is associated with a wide range of human lymphoproliferative disorders (LPD) of B, T, and natural killer (NK)-cell lineage. In children, abnormal immune response to primary EBV...
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Epstein-Barr Virus-associated Gastric Carcinoma

Lee BE

Epstein-Barr virus-associated gastric carcinoma (EBVaGC) comprises approximately 10% of all gastric cancers and is now defined as one of the four subtypes of gastric cancer according to the molecular classification...
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Nicotinamide adenine dinucleotide phosphate oxidase inhibitor induces apoptosis on EpsteinBarr virus positive B lymphoma cells

Ryu CH, Kim SH, Hur DY

Over-expression of nicotinamide adenine dinucleotide phosphate oxidase (Nox) isoform enzymes was recently reported in various cancers including Burkitt’s lymphoma (BL). However, the functions of Nox isoform enzymes in BL remain...
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Analysis of the Change in Seropositive Rate of the Epstein-Barr Virus in Koreans: A Single-Center Study

Kim SK, Choi JS, Kim D, Kang CI, Chung DR, Peck KR, Kang ES, Kim YJ

Purpose: Epstein-Barr virus (EBV) infection is related to infectious mononucleosis or nasopharyngeal cancer, and its epidemiology may change according to the socioeconomic development of communities. This study aimed to evaluate...
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Bilateral Breast Metastases from Epstein-Barr Virus-Associated Gastric Cancer during Pregnancy: Is There a Method to Its Madness?

Quaquarini E, Vanoli A, Frascaroli M, Viglio A, Lucioni M, Presti D, Lobascio G, Pietrabissa A, Bernardo A, Paulli M

Breast metastases of extramammary malignant neoplasms are rare, with an incidence of 0.3%–2.7% among all malignant mammary tumors. Breast metastases from gastric carcinoma are very rare (
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Epstein-Barr Virus-related Corneal Endotheliitis Accompanied with Secondary Glaucoma

Cho YW, Kang HJ, Kim GN, Kim HA, Chung IY, Kim SJ

PURPOSE: To report a case of Epstein-Barr virus-related corneal endotheliitis accompanied by secondary glaucoma. CASE SUMMARY: A 73-year-old male presented with blurred vision in his right eye. In the ophthalmic evaluation,...
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