J Korean Acad Periodontol.  2008 Dec;38(4):621-628. 10.5051/jkape.2008.38.4.621.

Experimental study on the periodontal regenerative capacity of moldable synthetic peptide domain gel in degree III furcation defect of beagles

• Kim JB
• Park YJ
• Lee SC
• Kim TI
• Seol YJ
• Lee YM
• Gu Y
• Rhyu IC
• Han SB
• Chung CP

• KMID: 1999594
• DOI: http://doi.org/10.5051/jkape.2008.38.4.621

Abstract

PURPOSE
Osteopontin is one of the major non-collagenous protein of hard tissue. Use of peptide domain of biologically active protein has some advantages. The objective of this experimental study is evaluation of periodontal regenerative potency of synthetic peptide gel which containing collagen binding domain of osteopontin in the degree III periodontal defect of beagle dogs. MATERIAL AND METHODS: Experimental degree III furcation defect was made in the mandibular third and fourth premolar of beagles. Regenerative material was applied during flap operation. 8 weeks after regenerative surgery, all animals were sacrificed and histomorphometric measurement was performed to calculate the linear percentage of the new cementum formation and the volume percentage of new bone formation. RESULT: The linear percent of new cementum formation was 41.6% at control group and 67.1% at test group and there was statistically significant difference. The volume percent of new bone formation was 52.1% at control group and 58.9% at test group.
CONCLUSION
As the results of present experiment, synthetic peptide gel containing collagen binding domain of osteopontin significantly increase new bone and cementum formation in the degree III furcation defect of canine mandible.

Keyword

Collagen binding domain; Peptide domain; Regeneration; Osteopontin

MeSH Terms

Animals
Bicuspid
Collagen
Dental Cementum
Furcation Defects
Mandible
Osteogenesis
Osteopontin
Protein Structure, Tertiary
Regeneration
Collagen
Osteopontin