Obstet Gynecol Sci.  2015 Jan;58(1):46-52. 10.5468/ogs.2015.58.1.46.

The association between oxidative stress and bone mineral density according to menopausal status of Korean women

Affiliations
  • 1Department of Obstetrics and Gynecology, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea. jkjoo@pusan.ac.kr

Abstract


OBJECTIVE
The aim of this study is to investigate the association between oxidative stress and bone mineral density (BMD) according to menopausal status of Korean women.
METHODS
A total of 2,232 women who visited to the health promotion center at Pusan National University Hospital between 2010 and 2014 were included in this cross-sectional study. Laboratory tests, such as uric acid, albumin, total bilirubin, which were evaluated as a natural antioxidants. Homocysteine also was evaluated as a factor associated with oxidative stress. Correlation analyses and partial correlation coefficient between BMD scores and laboratory parameters associated with oxidative stress according to menopausal status were performed with Pearson test.
RESULTS
By correlation analysis, uric acid had only positive correlation with femur and lumbar BMD in premenopausal and postmenopausal group. But albumin and bilirubin, which were the other natural antioxidants, had no correlation with BMD except total bilirubin with femur BMD in postmenopausal group. Homocysteine had negative correlation with femur BMD in postmenopausal group. But there were different results in partial correlation coefficient adjusted by age and BMI. In premenopausal group, uric acid was still positive correlation with femur and lumbar BMD, whereas in postmenopausal group homocysteine had no correlation with femur BMD, total bilirubin and uric acid had no correlation with lumbar BMD. At the multiple logistic regressions, only age and menopause status, uric acid had correlation with BMD.
CONCLUSION
In this study, homocysteine had no correlation with BMD. But in natural antioxidant, uric acid had only positive correlation with BMD.

Keyword

Bone density; Homocysteine; Menopause; Uric acid

MeSH Terms

Antioxidants
Bilirubin
Bone Density*
Busan
Cross-Sectional Studies
Female
Femur
Health Promotion
Homocysteine
Humans
Logistic Models
Menopause
Oxidative Stress*
Uric Acid
Antioxidants
Bilirubin
Homocysteine
Uric Acid

Reference

1. Eisman J, Clapham S, Kehoe L. Australian BoneCare Study. Osteoporosis prevalence and levels of treatment in primary care: the Australian BoneCare Study. J Bone Miner Res. 2004; 19:1969–1975.
2. Hodgson SF, Watts NB, Bilezikian JP, Clarke BL, Gray TK, Harris DW, et al. American Association of Clinical Endocrinologists medical guidelines for clinical practice for the prevention and treatment of postmenopausal osteoporosis: 2001 edition, with selected updates for 2003. Endocr Pract. 2003; 9:544–564.
3. Kanis JA, Black D, Cooper C, Dargent P, Dawson-Hughes B, De Laet C, et al. A new approach to the development of assessment guidelines for osteoporosis. Osteoporos Int. 2002; 13:527–536.
4. Bai XC, Lu D, Bai J, Zheng H, Ke ZY, Li XM, et al. Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-kappaB. Biochem Biophys Res Commun. 2004; 314:197–207.
5. Lean JM, Davies JT, Fuller K, Jagger CJ, Kirstein B, Partington GA, et al. A crucial role for thiol antioxidants in estrogen-deficiency bone loss. J Clin Invest. 2003; 112:915–923.
6. Lean JM, Jagger CJ, Kirstein B, Fuller K, Chambers TJ. Hydrogen peroxide is essential for estrogen-deficiency bone loss and osteoclast formation. Endocrinology. 2005; 146:728–735.
7. Ames BN, Cathcart R, Schwiers E, Hochstein P. Uric acid provides an antioxidant defense in humans against oxidant-and radical-caused aging and cancer: a hypothesis. Proc Natl Acad Sci U S A. 1981; 78:6858–6862.
8. Reid IR, Ames RW, Evans MC, Sharpe SJ, Gamble GD. Determinants of the rate of bone loss in normal postmenopausal women. J Clin Endocrinol Metab. 1994; 79:950–954.
9. Cao G, Prior RL. Comparison of different analytical methods for assessing total antioxidant capacity of human serum. Clin Chem. 1998; 44:1309–1315.
10. Yavuz BB, Yavuz B, Halil M, Cankurtaran M, Ulger Z, Cankurtaran ES, et al. Serum elevated gamma glutamyltransferase levels may be a marker for oxidative stress in Alzheimer's disease. Int Psychogeriatr. 2008; 20:815–823.
11. Leboff MS, Narweker R, LaCroix A, Wu L, Jackson R, Lee J, et al. Homocysteine levels and risk of hip fracture in postmenopausal women. J Clin Endocrinol Metab. 2009; 94:1207–1213.
12. Van Meurs JB, Dhonukshe-Rutten RA, Pluijm SM, van der Klift M, de Jonge R, Lindemans J, et al. Homocysteine levels and the risk of osteoporotic fracture. N Engl J Med. 2004; 350:2033–2041.
13. Golbahar J, Hamidi A, Aminzadeh MA, Omrani GR. Association of plasma folate, plasma total homocysteine, but not methylenetetrahydrofolate reductase C667T polymorphism, with bone mineral density in postmenopausal Iranian women: a cross-sectional study. Bone. 2004; 35:760–765.
14. Morris MS, Jacques PF, Selhub J. Relation between homocysteine and B-vitamin status indicators and bone mineral density in older Americans. Bone. 2005; 37:234–242.
15. Mijatovic V, van der Mooren MJ. Homocysteine in postmenopausal women and the importance of hormone replacement therapy. Clin Chem Lab Med. 2001; 39:764–767.
16. Genant HK, Cooper C, Poor G, Reid I, Ehrlich G, Kanis J, et al. Interim report and recommendations of the World Health Organization Task-Force for Osteoporosis. Osteoporos Int. 1999; 10:259–264.
17. Kuyumcu ME, Yesil Y, Ozturk ZA, Cınar E, Kızılarslanoglu C, Halil M, et al. The association between homocysteine (hcy) and serum natural antioxidants in elderly bone mineral densitometry (BMD). Arch Gerontol Geriatr. 2012; 55:739–743.
18. De Haan JB, Cristiano F, Iannello R, Bladier C, Kelner MJ, Kola I. Elevation in the ratio of Cu/Zn-superoxide dismutase to glutathione peroxidase activity induces features of cellular senescence and this effect is mediated by hydrogen peroxide. Hum Mol Genet. 1996; 5:283–292.
19. Koningsberger JC, van Asbeck BS, van Faassen E, Wiegman LJ, van Hattum J, van Berge Henegouwen GP, et al. Copper, zinc-superoxide dismutase and hydrogen peroxide: a hydroxyl radical generating system. Clin Chim Acta. 1994; 230:51–61.
20. Sontakke AN, Tare RS. A duality in the roles of reactive oxygen species with respect to bone metabolism. Clin Chim Acta. 2002; 318:145–148.
21. Mody N, Parhami F, Sarafian TA, Demer LL. Oxidative stress modulates osteoblastic differentiation of vascular and bone cells. Free Radic Biol Med. 2001; 31:509–519.
22. Schett G, Saag KG, Bijlsma JW. From bone biology to clinical outcome: state of the art and future perspectives. Ann Rheum Dis. 2010; 69:1415–1419.
23. Menon KV, Angulo P, Weston S, Dickson ER, Lindor KD. Bone disease in primary biliary cirrhosis: independent indicators and rate of progression. J Hepatol. 2001; 35:316–323.
24. Ormarsdottir S, Ljunggren O, Mallmin H, Michaelsson K, Loof L. Increased rate of bone loss at the femoral neck in patients with chronic liver disease. Eur J Gastroenterol Hepatol. 2002; 14:43–48.
25. Bian LQ, Li RZ, Zhang ZY, Jin YJ, Kang HW, Fang ZZ, et al. Effects of total bilirubin on the prevalence of osteoporosis in postmenopausal women without potential liver disease. J Bone Miner Metab. 2013; 31:637–643.
26. Melhus H, Michaelsson K, Holmberg L, Wolk A, Ljunghall S. Smoking, antioxidant vitamins, and the risk of hip fracture. J Bone Miner Res. 1999; 14:129–135.
27. Maggio D, Barabani M, Pierandrei M, Polidori MC, Catani M, Mecocci P, et al. Marked decrease in plasma antioxidants in aged osteoporotic women: results of a crosssectional study. J Clin Endocrinol Metab. 2003; 88:1523–1527.
28. Tyagi N, Kandel M, Munjal C, Qipshidze N, Vacek JC, Pushpakumar SB, et al. Homocysteine mediated decrease in bone blood flow and remodeling: role of folic acid. J Orthop Res. 2011; 29:1511–1516.
29. Bucciarelli P, Martini G, Martinelli I, Ceccarelli E, Gennari L, Bader R, et al. The relationship between plasma homocysteine levels and bone mineral density in postmenopausal women. Eur J Intern Med. 2010; 21:301–305.
30. Dhonukshe-Rutten RA, Lips M, de Jong N, Chin A Paw MJ, Hiddink GJ, van Dusseldorp M, et al. Vitamin B-12 status is associated with bone mineral content and bone mineral density in frail elderly women but not in men. J Nutr. 2003; 133:801–807.
31. Fleming JT, Barati MT, Beck DJ, Dodds JC, Malkani AL, Parameswaran D, et al. Bone blood flow and vascular reactivity. Cells Tissues Organs. 2001; 169:279–284.
32. Hak AE, Polderman KH, Westendorp IC, Jakobs C, Hofman A, Witteman JC, et al. Increased plasma homocysteine after menopause. Atherosclerosis. 2000; 149:163–168.
33. Christodoulakos G, Panoulis C, Rizos D, Moustakarias T, Phocas I, Creatsas G. Homocysteine and folate levels in postmenopausal women. Maturitas. 2001; 39:161–167.
34. Wouters MG, Moorrees MT, van der Mooren MJ, Blom HJ, Boers GH, Schellekens LA, et al. Plasma homocysteine and menopausal status. Eur J Clin Invest. 1995; 25:801–805.
35. Andersson A, Brattstrom L, Israelsson B, Isaksson A, Hamfelt A, Hultberg B. Plasma homocysteine before and after methionine loading with regard to age, gender, and menopausal status. Eur J Clin Invest. 1992; 22:79–87.
36. Kim A, Lee JH, Lee JY, Oh YM, Hong SN, Choi H, et al. Association between serum homocysteine concentrations and bone mineral density in middle aged women. J Korean Soc Menopause. 2013; 19:81–86.
37. Rasmussen K, Møller J. Total homocysteine measurement in clinical practice. Ann Clin Biochem. 2000; 37:627–648.
38. Carmel R, Green R, Jacobsen DW, Rasmussen K, Florea M, Azen C. Serum cobalamin, homocysteine, and methylmalonic acid concentrations in a multiethnic elderly population: ethnic and sex differences in cobalamin and metabolite abnormalities. Am J Clin Nutr. 1999; 70:904–910.
39. Cravo ML, Gloria LM, Selhub J, Nadeau MR, Camilo ME, Resende MP, et al. Hyperhomocysteinemia in chronic alcoholism: correlation with folate, vitamin B-12, and vitamin B-6 status. Am J Clin Nutr. 1996; 63:220–224.
40. Kapus O, Gaba A, Svoboda Z, Botek M. Relationship between body composition and bone mineral density of the lumbar spine and proximal femur: influence of years since menopause. Mod Rheumatol. 2014; 24:505–510.
41. Ishii S, Miyao M, Mizuno Y, Tanaka-Ishikawa M, Akishita M, Ouchi Y. Association between serum uric acid and lumbar spine bone mineral density in periand postmenopausal Japanese women. Osteoporos Int. 2014; 25:1099–1105.
Full Text Links
  • OGS
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr