Korean J Obstet Gynecol.  2000 Nov;43(11):1979-1982.

Comparison of bone mineral density in premature ovarian failure patients and spontaneous menopausal women

• Han MS
• Hwang TY

Abstract

OBJECTIVE
It is widely accepted that the estrogen plays an important role in the maintenance of bone mineral density (BMD). The purpose of this study is to compare the BMD between premature ovarian failure (POF) patients and spontaneous menopausal women, both of which are characterized by estrogen deficiency. METHOD: We compared the BMD of Lumbar 2-4 and Femur neck(right) measured by dual energy X-ray absorptiometry in 17 premature ovarian failure patients and 21 spontaneous menopausal women. RESULTS: POF patients and spontaneous menopausal women showed the BMD of 1.000+/-0.165g/cm2, 1.167+/-0.279g/cm2 at Lumbar 2-4 and 0.793+/-0.132g/cm2, 0.885+/-0.128g/cm2 at Femur neck, respectively. POF patients had lower BMD of Lumbar 2-4 and Femur neck significantly(p<0.05). FSH and estradiol level were not different between the two groups. CONCLUSION: This study demonstrated that the BMD in POF patients was decreased more severely than that of spontaneous menopausal women. Therefore, more preventive measures against bone loss is required in POF patients than spontaneous menopausal women.

Keyword

premature ovarian failure; spontaneous menopause; bone mineral density

MeSH Terms

Absorptiometry, Photon
Bone Density*
Estradiol
Estrogens
Female
Femur
Femur Neck
Humans
Primary Ovarian Insufficiency*
Estradiol
Estrogens