Korean J Otorhinolaryngol-Head Neck Surg.  2009 Nov;52(11):869-873. 10.3342/kjorl-hns.2009.52.11.869.

Survival of Spiral Ganglion

Affiliations
  • 1Department of Otolaryngology-Head and Neck Surgery, Gachon University of Medicine & Science, Graduate School of Medicine, Incheon, Korea. chochmd@gilhospital.com

Abstract

Survival and regeneration of spiral ganglion neuron (SGN) following deafening carries critical implication for cochlear implantation as well as reinnervation of restored hair cells. Survival and development of SGN depend on neurotrophic factors supplied by hair cells glial cells and other targets. The membrane electrical activity of spiral ganglion neurons also support their survival. Cell death inhibitors can also preserve spiral ganglion neurons. Recent studies of spiral ganglion survival including stem cell transplantation have identified several neurotrophic factors which protect neurons from death following hair cell loss. Although these experimental results are still preliminary, progression in study of strategy for SGN survival should be an important part of future neurobiology.

Keyword

Spiral ganglion; Neurotophic factor; Survival; Regeneration
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