J Korean Pain Soc.  1997 May;10(1):42-47.

Continuous Antiemetic Effects of Single Intravenous Injection of Antiemetics during Postoperative Pain Control with Morphine

• Choi GS
• An CH
• Park SS
• Lim DG
• Baek WY
• Park JW

Abstract

BACKGROUND
This study was designed to evaluate the continuous effects of single intravenous injection of antiemetics on nausea and vomiting during continuous morphine injection for postoperative pain control.
METHODS
Prior to the study, we divided patients into two major groups according to the type of surgery performed intra-abdominal (Open: 0) and non intra-abdominal (Close: C). When patients regained orientation after routine general anesthesia, enflurane-O2-N2O, we injected bolus dose of morphine and started continuous injection of morphine for postoperative pain control (Group 1; Control). After bolus injection and just before continuous injection, we injected single dose of droperidol (Group II) or ondansetron (Group III). Mean arterial blood pressure, heart rate, pain score and symptom-therapy score were checked at 10 minutes, 4, 8, 16, 24, 36 hours after continuous morphine injection.
RESULTS
The pain score of group III was lower than group II (10 min.) and group I (24, 36 hours) in the open group. Symptom-therapy score of group III (10min., 4, 24 hours) and group II (10 min.) were lower than group I in the open group. In the close group, symptom-therapy score of group III (8 hours) was lower than group I.
CONCLUSIONS
Single intravenous injection of antiemetics have a tendency of lowering symptom-therapy score for 36 hours in spite of their relatively short elimination half-life.

Keyword

Analgesia, postoperative; Analgesics, morphine; Vomiting, nausea, ondansetron

MeSH Terms

Anesthesia, General
Antiemetics*
Arterial Pressure
Droperidol
Half-Life
Heart Rate
Humans
Injections, Intravenous*
Morphine*
Nausea
Ondansetron
Pain, Postoperative*
Vomiting
Antiemetics
Droperidol
Morphine
Ondansetron