Korean J Anesthesiol.  1988 Dec;21(6):914-919. 10.4097/kjae.1988.21.6.914.

Respiratory Effects of Reversal of Morphine Induced Respiratory Depression by Doxapram

• Kwon TH
• Lim HJ
• Shin JS

• KMID: 1933074
• DOI: http://doi.org/10.4097/kjae.1988.21.6.914

Abstract

Postoperative respirative depression is a major factor limiting the use and safety of intraoperative narcotics. The need for an effective and safe narcotic antagonist to reverse this side effect without complication persists more than three decades of research. While narcotic induced respiratory depression can be reversed by appropriate, specific narcotic antagonist, it has not been possible to nulify the frespiratory depressant effects of narcotic without simultaneously nullifying the analgesic effects. Doxspram hydrochloride, respiratory stimulant, has been found to be significantly potent and selectively respirogenic. The present study undertakes to determine whether doxapram is ablereverse the respiratory depressnat effect of mrphine without mullifying the analgesic effects. In this study, 20 patients in 29 ASA class l patients given intravenous morphine, 0.5mg/kg, for elective surgery, produce postoperative respiratory depression. Inadequate spontaneous respiration at the end of anesthesia were treated with doxapram. The results were as follows: 1) Doxapram (mean 21.6mg) was able to reverse the respiratory depressant effect of morphine without nullifying the analgesic effect. 2) There was no hemodynamic alteration during reversal.

Keyword

Analgesic; Morphine; Postoperative respiratory depression; Doxapram

MeSH Terms

Anesthesia
Depression
Doxapram*
Hemodynamics
Humans
Morphine*
Narcotics
Respiration
Respiratory Insufficiency*
Doxapram
Morphine
Narcotics