Korean J Dermatol.
1999 Oct;37(10):1528-1531.
Clearance of Actinic Keratosis Caused by the Prodrug of 5-Fluorouracil
- Affiliations
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- 1Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Korea.
Abstract
- Tegafur [1-(tetrahydro-2-furyl)-5-fluorouracil], the prodrug of 5-fluorouracil, is an anticancer agent. Several cutaneous reactions have been reported following systemic 5-fluorouracil for the treatment of malignancies. We report a patient with marked inflammation of the actinic keratosis following the use of tegafur for stomach carcinoma. The side-effect with 5-fluorouracil was beneficial as most actinic keratosis cleared following the inflammatory reaction. Dermatologists and oncologists should be aware of this potential side-effect, not only because it may become more prevalent but, most importantly, because it is not an allergic reaction to 5-fluorouracil but a dose-dependent response, and the chemotherapy may be continued in most patients.
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