Soonchunhyang Med Sci.  2014 Jun;20(1):31-34.

Rosai-Dorfman Disease Combined with Aortic Vasculitis, Arrhythmia, and Valvular Heart Disease

• Kim SI
• Han JY
• Park YH
• Lim JH
• Lee MH
• Kim CS
• Yi HG

Abstract

Rosai-Dorfman disease (RDD) is a rare and benign self-limited disorder with pathologic feature of the lymph node sinuses expanded by a proliferation of distinctive histiocytes. The most often involving site is bilateral cervical lymphadenopathy, followed by the skin and soft tissue. Treatment options, including steroid, chemotherapy, radiotherapy and debulking surgery depend on the symptoms or the extent and localization of the lesions. We encountered a very rare case of RDD at the skin lesions, particularly combined with aortic vasculitis, arrhythmia, and valvular heart disease.

Keyword

Rosai-Dorfman disease; Vasculitis; Cardiac arrhythmia; Heart valve diseases; Prednisolone; Methotrexate

MeSH Terms

Arrhythmias, Cardiac*
Drug Therapy
Heart Valve Diseases*
Histiocytes
Histiocytosis, Sinus*
Lymph Nodes
Lymphatic Diseases
Methotrexate
Prednisolone
Radiotherapy
Skin
Vasculitis*
Methotrexate
Prednisolone