Korean J Nephrol.
2002 Sep;21(5):728-733.
Differential Regulation of Atrial Natriuretic Peptide in Clipped and Contralateral Kidneys in Two-Kidney, One Clip Hypertension
- Affiliations
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- 1Department of Physiology, Chonnam National University Medical School, Gwangju, Korea. julee@jnu.ac.kr
- 2Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
Abstract
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BACKGROUND: The present study was aimed to determine the pathophysiological implications of local atrial natriuretic peptide (ANP) system in the kidney in two- kidney, one clip (2K1C) hypertension.
METHODS
Rats were made 2K1C hypertensive, and their mRNA expressions of ANP and natriuretic peptide receptors (NPR) were determined in the clipped and contralateral kidneys by reverse transcription-polymerase chain reaction.
RESULTS
The expression of ANP was decreased in the clipped kidney and increased in the contralateral kidney. Similarly, the expression of both NPR-A and NPR-C was decreased in the clipped kidney and increased in the contralateral kidney.
CONCLUSION
These findings indicate a differentially-altered ANP system in the clipped and the contralateral kidneys in 2K1C hypertension.
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