Korean J Gastrointest Endosc.  1998 Aug;18(4):499-505.

Effect of Low - Dose Midazolam for Colonoscopy

Affiliations
  • 1Department of Internal Medicine, Sung Kyun Kwan University College of Medicine, Seoul, Korea.

Abstract

BACKGROUND/AIMS
Because colonoscopy is a painful procedure, analgesics and sedatives may be necessary as premedication. Midazolam reacts quicker, has a more excellent amnesic effect and fewer complications compared to diazepam. The effects of midazolam depend on dose, age, and rapidity of injection. According to several studies, side effects of midazolam were more common in high-dose injections (more than 5 mg) compared to low dose injections (0.03-0.05 rng/kg). Moreover, low dose injections were found to be as effective as high dose injections. However, there was no report about the effect and the side effects of midazolam in Korea. Therefore, we performed this study to determine the effect of low dose midazolam as premedication for colonoscopy.
METHODS
We performed colonoscopy in 99 consecutive patients who were randomly selected (midazolam group: 50, placebo group: 49) prospectively from July 1996 to September 1996. Premedication was administered through intravenous injection of midazolam or saline 0.03 mg/kg, combined with intramuscular injections of meperidine 50 mg, and intravenous injections of Buscopan 20 mg in all patients. Blood pressure, puise rate, and O2 saturation by oxymeter were checked before, during, and 30 minutes after colonoscopy. The degree of amnesia, discomfort, cooperation and acceptance of the re-examination were checked.

Keyword

Midazolam; Colonoscopy; Amnesia

MeSH Terms

Amnesia
Analgesics
Blood Pressure
Butylscopolammonium Bromide
Colonoscopy*
Diazepam
Humans
Hypnotics and Sedatives
Injections, Intramuscular
Injections, Intravenous
Korea
Meperidine
Midazolam*
Premedication
Prospective Studies
Analgesics
Butylscopolammonium Bromide
Diazepam
Hypnotics and Sedatives
Meperidine
Midazolam
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