Korean J Otorhinolaryngol-Head Neck Surg.  2013 Sep;56(9):545-549. 10.3342/kjorl-hns.2013.56.9.545.

Eosinophilic Chronic Rhinosinusitis

Affiliations
  • 1Department of Otorhinolaryngology, School of Medicine, Catholic University of Daegu, Daegu, Korea. hsseung@cu.ac.kr

Abstract

Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of the nasal and paranasal sinus mucosa. Generally CRS can classify depend on the presence of polyps or eosinophilic infiltration. Eosinophils have immune-modulatory effects on the inflammatory response of CRS and eosinophilia has been noted to be a marker for more extensive disease. Eosinophilic CRS (ECRS) is a clinical entity of chronic inflammation accompanied by numerous infiltrations of eosinophils in sinonasal tissues. The purpose of this review is to define and characterize the potential subcategories of ECRS and to discuss pathophysiology for targeted treatment modalities. Although it is difficult to differentiate one form of ECRS from another, genetic and molecular study will lead to unreveal the immunologic mechanism and pathogenesis of ECRS.

Keyword

Chronic rhinosinusitis; Eosinophils; Pathophysiology
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