J Korean Soc Menopause.  2010 Apr;16(1):16-22.

The Association between Serum Estradiol Level and Coronary Artery Calcification in Postmenopausal Women: A Preliminary Report

Affiliations
  • 1Department of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. kimsung@amc.seoul.kr
  • 2Department of Obstetrics and Gynecology, Haundae Paik Hospital, Inje University College of Medicine, Busan, Korea.

Abstract


OBJECTIVES
To estimate whether coronary artery calcification in postmenopausal women is associated with serum estradiol level.
METHODS
The present study retrospectively examined the clinical records of 162 postmenopausal women who visited the Health Promotion Center for a routine checkup and underwent a multidetector CT scan of the heart. Serum estradiol level, coronary heart disease (CHD) risk factors, current hormone therapy status, and BMD of the lumbar vertebrae and femoral neck were analyzed in women with coronary artery calcium score (CACS) > or = 100 and < 100.
RESULTS
Compared to women with higher CACS (> or = 100), women with lower CACS (< 100) had a significantly higher level of serum estradiol (27.34 +/- 2.96 vs. 13.31 +/- 1.10 pg/ml, P = 0.030) and lower mean age (57.63 +/- 0.44 vs. 61.88 +/- 1.90, P = 0.037). Women with CACS < 100 were significantly more likely to have a serum estradiol level greater than 20 pg/ml (42.25 vs. 0 %, P = 0.022) and lower prevalence of hypertension (28.17 vs. 62.50%, P = 0.053, borderline significant). However, multiple logistic regression analysis showed that any factors did not have a significant association with CACS except hypertension (OR 5.831 [95% CI 1.035 to 32.85], P = 0.046).
CONCLUSION
Serum estradiol level might be associated with the degree of calcification of coronary artery in postmenopausal women.

Keyword

Estradiol; Coronary artery calcification; Postmenopause; Hormone therapy

MeSH Terms

Calcium
Coronary Disease
Coronary Vessels
Estradiol
Female
Femur Neck
Health Promotion
Heart
Humans
Hypertension
Logistic Models
Lumbar Vertebrae
Postmenopause
Prevalence
Retrospective Studies
Risk Factors
Calcium
Estradiol
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