Korean J Nephrol.  2011 Mar;30(2):187-190.

Concurrence of Fibrillary Glomerulonephritis and AL Amyloidosis Associated with Monoclonal Gammopathy

Affiliations
  • 1Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Republic of Korea. kwlee@cnu.ac.kr
  • 2Department of Department of Pathology, Chungnam National University Hospital, Daejeon, Republic of Korea.

Abstract

Renal diseases with organized deposits include amyloid, fibrillary, immunotactoid, and cryoglobulinemic glomerulopathies. AL amyloidosis and fibrillary glomerulonephritis are different in the composition of their immunoglobulin deposits. Fibrils of fibrillary glomerulonephritis are usually composed of polyclonal, occasionally oligoclonal or monoclonal, immunoglobin G, but amyloidosis consists of monoclonal light chains. Simultaneous occurrence of fibrillary glomerulonephritis and AL amyloidosis is very rare. We report a case of fibrillary glomerulonephritis combined with AL amyloidosis in a 71-yr-old man.

Keyword

Amyloidosis; Glomerulonephritis; Monoclonal gammopathy of undetermined significance
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