J Clin Neurol.  2007 Jun;3(2):116-119. 10.3988/jcn.2007.3.2.116.

Polyneuropathy Associated with IgA Paraproteinemia and Amyloidosis: A Case Report and Literature Review

• Jhang Y
• Lee JJ
• Park JM
• Koo JS
• Kim BK
• Kwon O

• KMID: 1851025
• DOI: http://doi.org/10.3988/jcn.2007.3.2.116

Abstract

Paraproteinemia potentially causes peripheral neuropathy via an unknown underlying pathogenetic mechanism. We report a case of pathologically proven amyloid neuropathy with AL amyloidosis with an IgA kappa light chain, which was initially diagnosed as neuropathy associated with monoclonal gammopathy of undetermined significance. This case indicates that in cases of neuropathy with paraproteinemia, the other potential causes should be excluded by appropriate means, especially pathological evaluations.

Keyword

Amyloidosis; Paraproteinemia; Polyneuropathy

MeSH Terms

Amyloid Neuropathies
Amyloidosis*
Immunoglobulin A*
Monoclonal Gammopathy of Undetermined Significance
Paraproteinemias*
Peripheral Nervous System Diseases
Polyneuropathies*
Immunoglobulin A