J Korean Epilepsy Soc.  2006 Jun;10(1):31-34.

Lack of Association between L48V Polymorphism in the UGT1A4 Gene and Lamotrigine-induced Rash

• Kim DW
• Kim M
• Lee SK
• Kang R
• Lee SY

Abstract

PURPOSE: The aim of the present study was to determine whether an association exists between UGT1A4 gene polymorphisms (P24T and L48V) and the occurrence of lamotrigine (LTG)-induced rash.
METHODS
Ten patients with LTG-induced rash were examined for the P24T and L48V genetic polymorphisms. The results were compared with 42 epilepsy patients without LTG-induced rash and 143 non-exposure epilepsy patients.
RESULTS
P24T polymorphism was not found; all studied subjects were homozygous for the 24P allele. Genetic heterogeneity of the L48V polymorphism existed, but the genetic proportions and allele frequencies of L48V polymorphism were not significantly different in the three groups of patients (p>0.05, by Fisher's Exact Test).
CONCLUSION
The results of our study suggest that it is unlikely that the L48V polymorphism in the UGT1A4 gene is an important factor underlying LTG-induced rash development, especially in the absence of P24T polymorphism.

Keyword

Lamotrigine; Rash; Polymorphism; UGT1A4

MeSH Terms

Alleles
Epilepsy
Exanthema*
Gene Frequency
Genetic Heterogeneity
Humans
Polymorphism, Genetic