Psychiatry Investig.  2008 Jun;5(2):121-123. 10.4306/pi.2008.5.2.121.

Three Cases of Reversible Agranulocytosis after Treatment with Lamotrigine

  • 1Department of Psychiatry, and Behavioral Science, Seoul National University College of Medicine, Seoul, Korea.


Several psychotropic drugs, including clozapine, are known to cause agranulocytosis and this may lead to a fatal condition. Lamotrigine is an anticonvulsant that the Food and Drug Administration (FDA) has approved for the depression of bipolar disorder. A few cases of lamotrigine-induced agranulocytosis have been previously reported on, but the pathophysiology and clinical manifestations are not yet known. This case series reports on 3 patients with different medical conditions who experienced agranulocytosis during treatment with lamotrigine. In these cases, the agranulocytosis occurred a few weeks after initiation of lamotrigine and it rapidly disappeared after discontinuation. We also discuss several characteristics of lamotrigine-induced agranulocytosis.


Lamotrigine; Agranulocytosis; Bipolar disorder
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