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Can Aminoglycosides Be Used as a New Treatment for Helicobacter pylori? In vitro Activity of Recently Isolated Helicobacter pylori

Lee KH, Park SY, Jeong SJ, Jung DH, Kim JH, Jeong SH, Kang IM, Song YG

BACKGROUND: Smectite can serve as a drug delivery system and gentamicin-intercalated smectite hybrids are expected to supersede the standard therapy for Helicobacter pylori eradication. The aim of this study was...
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ArmA and RmtB Were the Predominant 16S RMTase Genes Responsible for Aminoglycoside-resistant Isolates in Korea

Lee TH, Hwang JH, Lee WK, Shin MK, Woo HR, Chung KM, Lee CS

Pathogenic gram-negatives that produce 16S ribosomal RNA methyltransferases (16S RMTases) have already been distributed all over the world. To investigate the predominance of aminoglycoside resistance associated with 16S RMTases in...
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Antimicrobial Susceptibility and Clonal Distribution of the Blood Isolates of Pseudomonas aeruginosa from Two Korean Hospitals

Kim CH, Lee JC

An increasing prevalence of infections caused by multidrug-resistant (MDR) Pseudomonas aeruginosa (P. aeruginosa) causes a serious therapeutic problem in clinical setting. This study investigated the antimicrobial susceptibility, resistance mechanisms against...
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Effectiveness of sugammadex in reversing prolonged neuromuscular block in a patient with acquired immune deficiency syndrome (AIDS) taking streptomycin: A case report

Kim JM, Kim KS, Koo MS

The duration of the effect of muscle relaxants is extended in patients with acquired immunodeficiency syndrome (AIDS); however, a specific mechanism for this effect has not yet been discovered. In...
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Asymmetric Audiovestibular Dysfunction in Patients With Systemic Aminoglycoside Treatment

Park JH, Rah YC, Kim JS, Koo JW

  • KMID: 1426866
  • Res Vestib Sci.
  • 2013 Jun;12(2):62-66.
Since the characteristics of aminoglycoside ototoxicity is typically bilaterally symmetric progression of cochlea-vestibular dysfunction, a unilateral involvement has rarely been reported. However, ototoxicity can be asymmetric or focal after systemic...
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The Genetic Characteristics of Multidrug-resistant Acinetobacter baumannii Coproducing 16S rRNA Methylase armA and Carbapenemase OXA-23

Lim J, Cho HH, Kim S, Kim J, Kwon KC, Park JW, Koo SH

Acinetobacter baumannii is a gram-negative organism reported worldwide as a cause of health-care associated infections. Due to its increasing drug resistance, several studies on coproduction of armA and carbapenemase in...
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Update of Research on Aminoglycoside Ototoxicity

Byun JY

It has long been known that the major irreversible toxicity of aminoglycosides is ototoxicity. Among them, streptomycin and gentamicin are primarily vestibulotoxic, whereas amikacin, neomycin, dihydrosterptomycin, and kanamicin are primarily...
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Molecular and Phenotypic Characteristics of 16S rRNA Methylase-producing Gram-negative Bacilli

Lee H, Koh EM, Kim CK, Yum JH, Lee K, Chong Y

BACKGROUND: Recently a novel plasmid-mediated resistant mechanism that conferred high-level resistance to aminoglycoside via methylation of 16S rRNA was reported. The aims of this study were to determine the prevalence...
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Aminoglycoside Resistance in Gram-negative Bacilli

Park YJ

Aminoglycosides are one of the clinically relevant antibiotics. They kill bacteria by binding to bacterial 30S subunit of ribosome. Resistance to aminoglycosides occurs by three different mechanisms: 1. Production of...
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Multicenter study on the treatment pattern of Meniere'sdisease in Korea

Hong SK, Koh EK, Kim KS, Park KH, Park HJ, Ahn SK, Ahn JH, Lee WS, Im GJ, Jung JY, Chung WH, Han GC, Chae SW, Koo JW

  • KMID: 2328932
  • J Korean Bal Soc.
  • 2008 Dec;7(2):174-181.
BACKGROUND AND OBJECTIVES: It is hard to determine the efficacy of several treatment options of Meniere's disease since dynamic course of the disease and diverse rate of recurrence. Few modalities...
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Once daily dosing of aminoglycoside in children

Shin SH

Aminoglycosides are frequently used antibiotics in children. The multiple daily dosing (MDD) in infants and children is twice or three times daily depending on age. Recent studies in adults have...
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Therapeutic Drug Monitoring (TDM) of Antimicrobial Agents

Kim SW

Optimal exposure of certain antimicrobials and minimization of their toxicity can be achieved by therapeutic drug monitoring (TDM) of antimicrobial agents. Vancomycin and aminoglycosides are most frequently monitored because of...
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Distribution of Genes Encoding Aminoglycoside Modifying Enzymes and Type Staphylococcal Chromosomal Cassette mec in Methicillin-resistant Staphylococcus aureus from Non-tertiary Hospitals

Jung YH, Kim KW, Cha JO, Lee KM, Yoo JI, Yoo JS, Kim BS, Oh YJ, Yoon HR, Lee YS

BACKGROUND: Many genes encoding aminoglycoside modifying enzymes (AMEs) on transposon or plasmid were transferred from one strain to another strain and inserted into a staphylococcal chromosomal cassette mec (SCCmec). There...
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Effects of puromycin aminonucleoside on the cytoskeletal changes of glomerular epithelial cells

Lee JH, Ha TS

PURPOSE:This study was designed to clarify the mechanism of proteinuria in nephrotic syndrome patients by using puromycin aminonucleoside (PAN) nephrosis model. METHODS:Following administration of various concentrations of PAN and antioxidants we...
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In Vitro Activities of Isepamicin and Other Aminoglycosides against Gram-Negative Organisms

Kwon HH, Park SJ, So MW, Park HG, Choi SH, Kim MN, Choi SH, Jeong JY, Woo JH, Kim YS

  • KMID: 2285065
  • Infect Chemother.
  • 2006 Dec;38(6):356-361.
BACKGROUND: The increasing incidence of multidrug-resistant gram-negative bacteria causing nosocomial infections is an important clinical problem. Isepamicin is a recently developed aminoglycoside which has been known to have potent activity...
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Comparison of two dosing regimens of aminoglycosides for the development of nephrotoxicity: once versus multiple daily dosing

Choi BD, Kim BN

  • KMID: 2305955
  • Korean J Med.
  • 2006 Nov;71(5):543-550.
BACKGROUND: Aminoglycosides are useful for the treatment of aerobic gram-negative infections, and this is despite the narrow therapeutic index and the potential nephrotoxicity and ototoxicity. Once daily dosing of aminoglycosides...
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Effects of Aminoglycoside Antibiotics on Acetylcholine-induced Potassium Currents in Guinea-pig Outer Hair Cell

Lee JK, Cho HH, Moon SJ, Kook JH, Jang MJ, Jeong HS, Cho YB, Park JS

  • KMID: 2276510
  • Korean J Otolaryngol-Head Neck Surg.
  • 2005 Nov;48(11):1329-1335.
BACKGROUND AND OBJECTIVES: Aminoglycoside antibiotics are widely used for the treatment of infection caused by Gram-negative bacilli, but prolonged exposure to it can cause permanent hearing loss since are reported...
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Changes in Activity of Vestibular Afferents after Intratympanic Gentamicin Single Injection

Park HJ

  • KMID: 1597335
  • Korean J Otolaryngol-Head Neck Surg.
  • 2005 May;48(5):589-595.
BACKGROUND AND OBJECTIVES: Aminoglycoside antibiotics are toxic to hair cells of the inner ear. Recently, intratympanic gentamicin injection is widely accepted as a treatment modality for Meniere's disease. SUBJECTS AND...
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Effect of Antioxidants on Aminoglycoside-induced Cochlear Cell Damage

Nam SI

  • KMID: 2298432
  • Korean J Aerosp Environ Med.
  • 2005 Apr;15(1):18-22.
BACKGROUND: Aminoglycosides that are widely used in the treatment of Gram (-)-infected diseases have side effects such as ototoxicity and nephrotoxicity. These side effects are closely related to oxidative stress....
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Usage Analysis of Surgical Prophylaxis of Cephalosporins and Aminoglycosides in a University Hospital

Rheem I, Pai H, Choi EK, Oh HT, Choi DO, Park WS

  • KMID: 1808195
  • Infect Chemother.
  • 2004 Feb;36(1):24-31.
BACKGROUND: According to previous investigation on antibiotic use at Dankook University Hospital, cephalosporin and aminoglycoside were the most commonly used antibiotics accounting for 52.8% and 30.4% of total antibiotics used,...
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