Ann Lab Med.  2014 Mar;34(2):163-165. 10.3343/alm.2014.34.2.163.

A Case of Residual Non-Small Cell Lung Cancer Cells Coexisting With Newly Developed Small Cell Lung Cancer Cells in Ascitic Fluid after Chemotherapy for Non-Small Cell Lung Cancer

• Park SH
• Chi HS
• Kim YJ
• Cho YU
• Jang S
• Park CJ
• Kim SW

• KMID: 1791913
• DOI: http://doi.org/10.3343/alm.2014.34.2.163

Abstract

No abstract available.

MeSH Terms

Antineoplastic Agents/therapeutic use
Ascitic Fluid/*cytology
Carcinoma, Non-Small-Cell Lung/*diagnosis/drug therapy/pathology
Humans
Lung Neoplasms/*diagnosis/drug therapy/pathology
Lymphatic Metastasis
Male
Middle Aged
Mutation
Neoplasm Staging
Quinazolines/therapeutic use
Receptor, Epidermal Growth Factor/genetics
Small Cell Lung Carcinoma/*diagnosis/pathology
Tomography, X-Ray Computed
Antineoplastic Agents
Receptor, Epidermal Growth Factor
Quinazolines

Figure

• 

  Fig. 1 Wright staining of ascitic fluid cytospin slides. Two types of neoplastic cells were detected (A, 400×, small-cell lung cancer [SCLC] cells pointed by black arrow and non-small cell lung cancer [NSCLC] cells by red arrow) at a frequency of 18%. Small-to medium-sized SCLC cells appeared as clusters of tumor cells with a back-to-back appearance (B, 400×, black arrow), and the second type of cells, large NSCLC cells, showed mucinous contents in the cytoplasm (C, 400×, red arrow).

• 

  Fig. 2 Cytochemical and immunocytochemical staining results of the two types of neoplastic cells detected in the ascitic fluid. The small-to medium-sized small-cell lung cancer cells (black arrow) showed membrane positivity for CD56 on immunocytochemical staining (A, 400×). The large non-small cell lung cancer cells (red arrow) showed cytoplasmic positivity with periodic acid-Schiff cytochemical staining (B, 1,000×) as well as cytokeratin 7 positivity on immunocytochemical staining (C, 400×) but cytokeratin 20 negativity on immunocytochemical staining (D, 400×).

Reference

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