Korean J Lab Med.  2008 Dec;28(6):413-418. 10.3343/kjlm.2008.28.6.413.

Correlation of Chromosomal Aberrations with Prognostic Markers in Multiple Myeloma Patients- A Single Institution Study

Affiliations
  • 1Department of Laboratory Medicine, Korea Cancer Center Hospital, Seoul, Korea. cyhlabo@kcch.re.kr

Abstract

BACKGROUND
Immunoglobulin heavy chain (IGH) gene rearrangement, 13q14 deletion and trisomy 1q are frequently observed in Korean patients with multiple myeloma. The purpose of our study was to analyze the statistical correlation between chromosomal aberrations and routine laboratory test results as prognostic markers and to evaluate the potential of chromosomal aberrations for the indirect assessment of prognosis in multiple myeloma patients.
METHODS
We investigated the prevalence of cytogenetic aberrations in 41 patients with newly diagnosed multiple myeloma. Cytogenetic analysis was conducted by conventional karyotyping and FISH for the presence of IGH/CCND1 translocation, 13q14 deletion, and trisomy 1q using bone marrow aspirates. The records of routine laboratory tests were reviewed and their correlation with cytogenetic abnormalities was investigated.
RESULTS
Sixteen (39.0%) of 41 patients had at least one cytogenetic abnormalities in conventional karyotyping or FISH. In FISH analysis of 37 patients, 8 (21.6%) showed positive result for IGH/CCND1 translocation, 8 (21.6%) for trisomy 1q, and 5 (13.5%) for 13q14 deletion. Cytogenetic abnormalities, especially trisomy 1q, were associated with significantly lower hemoglobin level and significantly higher bone marrow plasma cell percentage and beta2-microglobulin level.
CONCLUSIONS
Statistical correlation between the presence of trisomy 1q and prognostic markers suggests that the evaluation of trisomy 1q in multiple myeloma patients may be used for the indirect assessment of prognosis in these patients.

Keyword

Multiple myeloma; Cytogenetic abnormalities; Trisomy 1q

MeSH Terms

Adult
Aged
*Chromosome Aberrations
*Chromosomes, Human, Pair 1
*Chromosomes, Human, Pair 13
Female
Humans
Immunoglobulin Heavy Chains/genetics
In Situ Hybridization, Fluorescence
Karyotyping
Male
Middle Aged
Multiple Myeloma/*diagnosis/genetics
Prognosis
Translocation, Genetic
Trisomy/genetics
Tumor Markers, Biological/*blood
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