Kosin Med J.  2013 Jun;28(1):35-41. 10.7180/kmj.2013.28.1.35.

The Association Between Serum GGT Level and Bone Mineral Density in Postmenopausal Women

Affiliations
  • 1Department of Obstetrics and Gynecology, College of Medicine, Kosin University, Busan, Korea.
  • 2Department of Family Medicine, College of Medicine, Kosin University, Busan, Korea. eh-kong@kosin.ac.kr

Abstract


OBJECTIVES
The aim of this study was to identify the relationship between serum gamma-glutamyltransferase (GGT) and bone mineral density (BMD) in postmenopausal women.
METHODS
We evaluated 200 postmenopausal women who were visiting a health promotion center at a university hospital from January 2009 to December 2011. Their current medical diseases and medication history were collected through medical records. Basic physical examinations and laboratory tests were performed on all subjects.
RESULTS
The levels of serum GGT within their normal range were positively correlated with waist circumference (P = 0.01), triglycerides (P <0.001), alkaline phosphatase (P = 0.009), and uric acid (P = 0.01). The serum GGT within their normal range were negatively associated with the femur neck BMD (P = 0.002). In adjusted analysis including age and body mass index, the BMD of the femur neck was more strongly associated with a high-normal serum GGT level among the postmenopausal women as compared with those with a low-normal serum GGT level (P = 0.02).
CONCLUSIONS
Serum GGT within its normal range is negatively correlated with the BMD in the femur neck among postmenopausal women. It can be useful for selecting a group that is at high risk for the bone fracture regardless of the underlying mechanism.

Keyword

Bone mineral density; Gamma-glutamyl transferase; Postmenopause

MeSH Terms

Alkaline Phosphatase
Body Mass Index
Bone Density
Female
Femur Neck
Fractures, Bone
gamma-Glutamyltransferase
Health Promotion
Humans
Medical Records
Physical Examination
Postmenopause
Reference Values
Triglycerides
Uric Acid
Waist Circumference
Alkaline Phosphatase
Triglycerides
Uric Acid
gamma-Glutamyltransferase

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