Gut Liver.
2014 May;8(3):254-264.
Recent Chemotherapy Reduces the Maximum-Standardized Uptake Value of 18F-Fluoro-Deoxyglucose Positron Emission Tomography in Colorectal Cancer
- Affiliations
-
- 1Department of Internal Medicine and Liver Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea. kjwjor@snu.ac.kr
- 2Department of Internal Medicine, Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea.
- 3Department of Biostatistics, Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea.
Abstract
- BACKGROUND/AIMS
The aim of this study was to evaluate the influence of recent chemotherapy on the patterns of the maximum-standardized uptake value (M-SUV) and sensitivity of 18F-fluoro-deoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) in colorectal cancer.
METHODS
We retrospectively analyzed the FDG-PET/CT of 509 patients who underwent surgery for colorectal cancer. Subgroup analysis was performed according to chemotherapy status; 401 patients were not treated with chemotherapy and 108 patients were treated with chemotherapy within 6 months prior to surgery. Pathologic analysis of the surgical specimen was used as the gold standard.
RESULTS
The M-SUV was significantly lower in patients treated with chemotherapy than in those not treated with chemotherapy in pathologically confirmed same stages of disease. The difference in the sensitivity of the M-SUV according to chemotherapy status was greatest using a cutoff M-SUV value of 6.4 (p<0.001). The longest diameter of the primary tumor was the most important factor that correlated with M-SUV of the primary tumor irrespective of the chemotherapy effect (p<0.001). The M-SUV of the primary tumor was not an independent predictor of lymph node metastasis in colorectal cancer.
CONCLUSIONS
The results indicate that the M-SUV of FDG-PET/CT should be interpreted in the context of concurrent chemotherapy.
Keyword
MeSH Terms
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Aged
Antineoplastic Agents/*adverse effects
Chemoradiotherapy, Adjuvant/adverse effects
Chemotherapy, Adjuvant/adverse effects
Colorectal Neoplasms/drug therapy/pathology/*radionuclide imaging
Female
Fluorodeoxyglucose F18/diagnostic use/*pharmacology
Humans
Male
Neoplasm Invasiveness
Neoplasm Metastasis
Positron-Emission Tomography/methods
Radiopharmaceuticals/diagnostic use/*pharmacology
Retrospective Studies
Antineoplastic Agents
Fluorodeoxyglucose F18
Radiopharmaceuticals
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