Korean J Otolaryngol-Head Neck Surg.  2001 Mar;44(3):261-264.

Penetration of Cefprozil into Middle Ear Effusion in Pediatric Chronic Otitis Meida with Effusion

• Jang CH
• Kim YH
• Choi CI
• Lee JS

Abstract

BACKGROUND: From a pharmacokinetic standpoint, middle ear effusion (MEE) acts as a sequestered compartment since diffusion of antibiotics from serum and to this compartment is limited. The effectiveness of an antibiotic to eradicate infection within an anatomic compartment is related to both its ability to penetrate and the susceptibility of the causative pathogen.
OBJECTIVE
The goal of this study was to determine the steady state plasma and MEE concentrations of cefprozil in pediatric chronic otitis media with effusion (COME).
MATERIALS AND METHODS
Twenty-five children with COME were enrolled, and MEE was collected using a ventilation tube insertion after 0.5, 2, 3, 5, and 6 hours of single oral administration of 15 mg Cefprozil/kg body weight. Blood samples were also collected as soon as the MEE was collected, and analyzed in order to measure the concentration of Cefprozil using the validated high performance liquid chromatography (HPLC) method.
RESULTS
The mean concentrations of cefprozil in MEE ranged from 0.4 to 4.4 ug/ml. The penetration of cefprozil into the MEE was rapid and effectively. Cefprozil in the MEE was maintained at a greater level than MIC90 in Streptococcus pneumoniae for at least 6 hours after administration of 15mg/kg.
CONCLUSION
Cefprozil penetrates well into MEE in patients with pediatric COME.

Keyword

Chronic Otitis media with effusion; Cefprozil; Middle ear effusion; Penetration

MeSH Terms

Administration, Oral
Anti-Bacterial Agents
Body Weight
Child
Chromatography, Liquid
Diffusion
Ear, Middle*
Humans
Otitis Media with Effusion*
Otitis*
Plasma
Streptococcus pneumoniae
Ventilation
Anti-Bacterial Agents