Korean J Otolaryngol-Head Neck Surg.  2000 Jul;43(7):689-692.

Demonstration of Eosinophil Cationic Protein in Pediatric Chronic Otitis Media with Effusion Associated with Allergy

• Jang CH

Abstract

BACKGROUND AND OBJECTIVES: Allergy may play a role in pediatric chronic otitis media with effusion (COME). It is generally accepted that selective recruitment of eosinophils is important in the pathogenesis of the allergic rhinitis and asthma. Eosinophil cationic protein (ECP) is an identifiable mediator in additional target organs involved in allergic reactions. This study was designed to discover the relationship of ECP and positive allergy in persistent COME.
MATERIALS AND METHODS
Twenty patients with persistent COME were evaluated for ECP. Fifteen of these patients were confirmed allergy positive by MAST (multiple allergosorbent test). ECP in the middle ear effusions were measured using FEIA (fluoro-enzyme-immunoassay).
RESULTS
The ECP level was statistically higher in the positive MAST group than in the negative MAST group (p<0.01).
CONCLUSION
There was a correlation between ECP from middle ear effusion indeed was correlate with the patient having allergy, as confirmed by MAST.

Keyword

COME; Allergy; ECP

MeSH Terms

Asthma
Eosinophil Cationic Protein*
Eosinophils*
Humans
Hypersensitivity*
Otitis Media with Effusion*
Otitis Media*
Otitis*
Rhinitis
Eosinophil Cationic Protein