Yonsei Med J.
2005 Aug;46(4):532-538. 10.3349/ymj.2005.46.4.532.
Determination of Urinary Myo-/Chiro-Inositol Ratios from Korean Diabetes Patients
- Affiliations
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- 1Department of Internal Medicine, College of Natural Sciences, Gyeongsang National University, Jinju, Korea. jrhahm@gshp.gsnu.ac.kr
- 2Department of Biochemistry, College of Natural Sciences, Gyeongsang National University, Jinju, Korea.
- 3Department of Microbiology, College of Natural Sciences, Gyeongsang National University, Jinju, Korea.
- 4Gyeongsang Institute of Health Science, Jinju, Korea.
- KMID: 1716524
- DOI: http://doi.org/10.3349/ymj.2005.46.4.532
Abstract
- Of two major forms (myo- and chiro-inositol) of inositols, only chiro-inositol enhances the activity of proteins involved in intracellular glucose metabolism. This study aims to determine the urinary myo-/chiro-inositol ratio in type 1 and type 2 diabetes patients and compare its ratio with the normal control group. The 24-hour urinary myo- and chiro-inositols in 71 Korean diabetes patients and 39 control subjects have been quantified using high-performance liquid chromatography, and their ratios have been evaluated as indices of insulin resistance. The level of 24-hour urinary myo-inositol was significantly higher in both type 1 and type 2 diabetes than with the control group, whereas the urinary chiro-inositol in type 1 or type 2 diabetes was lower than that in normal subjects. The myo-/chiro-inositol ratio in diabetes patients was higher than that in the control group. Twenty four-hour urinary myo-/ chiro-inositol ratios were significantly elevated in type 1 and type 2 diabetes patients compared to the control group, suggesting that a high ratio of urinary myo-/chiro- inositol in type 2 diabetes patients might be used for an index of insulin resistance.
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