Korean J Otorhinolaryngol-Head Neck Surg.  2014 Aug;57(8):499-503. 10.3342/kjorl-hns.2014.57.8.499.

Current Status of Tympanic Membrane Regeneration Using Tissue Engineering Approach

• Jang CH
• Jo SY

• KMID: 1716008
• DOI: http://doi.org/10.3342/kjorl-hns.2014.57.8.499

Abstract

Tympanic membrane (TM) perforation is common. Acute persistent or chronic TM perforations require surgical interventions such as myringoplasty or tympanoplasty. Current strategies of tissue engineering are focused on the regeneration of TM perforation instead of surgical interventions. To regenerate TM tissue or restore acoustic-mechanical property, bioscaffold or growth factors are necessary that will act as a temporary matrix for cell proliferation and extracellular matrix deposition, with subsequent ingrowths. In recent years, various scaffolds, biomolecules have been used for TM tissue engineering. Cells in combination with supportive scaffolds have rarely reported. TM regeneration by tissue engineering approach may be considered the greatest advances in otology. This review examines the current evidence for their use and the limitations of knowledge.

Keyword

Regeneration; Tissue engineering; Tympanic membrane

MeSH Terms

Cell Proliferation
Extracellular Matrix
Intercellular Signaling Peptides and Proteins
Myringoplasty
Otolaryngology
Regeneration*
Tissue Engineering*
Tympanic Membrane*
Tympanoplasty
Intercellular Signaling Peptides and Proteins