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Effects of Androgen Receptor Overexpression on Chondrogenic Ability of Rabbit Articular Chondrocytes

Hui L, Shoumei X, Zhoujing Z, Kuang G, Duohong Z, Jiacai H, Yong Z

BACKGROUND: The role of sex hormones and their receptors has drawn much attention in the process of cartilage regeneration. This study aimed to investigate the effect of androgen receptor (AR)...
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Effect of TNF-α and IL-6 on Compact Bone-Derived Cells

Zhang Y, Li X, Chihara T, Dong H, Kagami H

Background: Although bone tissue engineering has already been applied clinically, its regeneration efficacy is not always sufficient. Local inflammatory cytokines are considered as the major factors that induce apoptosis of transplanted...
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Electrospun Microvasculature for Rapid Vascular Network Restoration

Han JH, Ko UH, Kim HJ, Kim S, Jeon JS, Shin JH

BACKGROUND: Sufficient blood supply through neo-vasculature is a major challenge in cell therapy and tissue engineering in order to support the growth, function, and viability of implanted cells. However, depending...
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Autologous blood derived cell therapy in maxillofacial bone graft surgery

Park JY

Tissue regeneration is one of the ultimate goals of maxillofacial surgery and various types of tissue engineering technologies have been utilized in clinics. Healthy resources of host cells and growth...
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Biomaterials-based Approaches for Cardiac Regeneration

Vasu S, Zhou J, Chen J, Johnston PV, Kim DH

The limited ability of cardiomyocytes to proliferate is a major cause of mortality and morbidity in cardiovascular diseases. There exist therapies for cardiac regeneration that are cell-based as well as...
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Patient-Specific Tumor Microenvironment Models

Lee JW, Kim J, Shin Y, Chi BH, Kim JH, Choi SY

The heterogeneity of cancer makes it difficult to predict the prognosis of treatment. There is still a lack of preclinical model systems that reflect the clinical characteristics of patients who...
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Comparative characteristic study from bone marrow-derived mesenchymal stem cells

Purwaningrum M, Jamilah NS, Purbantoro SD, Sawangmake C, Nantavisai S

Tissue engineering has been extensively investigated and proffered to be a potential platform for novel tissue regeneration. The utilization of mesenchymal stem cells (MSCs) from various sources has been widely...
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Biomimetic Biphasic Electrospun Scaffold for Anterior Cruciate Ligament Tissue Engineering

Tang Y, Tian J, Li L, Huang L, Shen Q, Guo S, Jiang Y

Background: Replacing damaged anterior cruciate ligaments (ACLs) with tissue-engineered artificial ligaments is challenging because ligament scaffolds must have a multiregional structure that can guide stem cell differentiation. Here, we designed a...
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Effect of Leukocyte-Platelet Rich Fibrin (L-PRF) on Tissue Regeneration and Proliferation of Human Gingival Fibroblast Cells Cultured Using a Modified Method

Mudalal M, Wang Z, Mustafa S, Liu Y, Wang Y, Yu J, Wang S, Sun X, Zhou Y

Background: An in vitro study on rapid culturing method of human gingival fibroblast cells (HGFCs) was established to investigate the potential use of the leukocyte-platelet rich fibrin (L-PRF) in tissue engineering...
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Nanofiber Scaffolds by Electrospinning for Rotator Cuff Tissue Engineering

Lim TK, Dorthé E, Williams A, D’Lima DD

Rotator cuff tears continue to be at risk of retear or failure to heal after surgical repair, despite the use of various surgical techniques, which stimulate development of novel scaffolding...
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Challenges of Engineering Biomimetic Dental and Paradental Tissues

Grawish ME, Grawish LM, Grawish HM, Grawish MM, El-Negoly SA

BACKGROUND: Loss of the dental and paradental tissues resulting from trauma, caries or from systemic diseasesconsidered as one of the most significant and frequent clinical problem to the healthcare professionals....
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Incorporation of Smooth Muscle Cells Derived from HumanAdipose Stem Cells on Poly(Lactic-co-Glycolic Acid) Scaffoldfor the Reconstruction of Subtotally Resected Urinary Bladderin Athymic Rats

Salem SA, Rashidbenam Z, Jasman MH, Ho CCK, Sagap I, Singh R, Yusof MR, Zainuddin ZM, Idrus RBH, Ng MH

BACKGROUND: The urinary tract can be affected by both congenital abnormalities as well as acquired disorders, such ascancer, trauma, infection, inflammation, and iatrogenic injuries, all of which may lead to...
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Current Concepts of Bone Healing

Suh DH, Koo BM, Kang JW

Bone injuries induce an inflammatory response that promotes bone healing. On the other hand, an aberrant process, where inflammation becomes chronic, can inhibit the healing of injured bone. At the...
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Current Concepts in the Articular Cartilage Repair

Yeo ED, Cho WJ, Lee YK

Articular cartilage defects are common in orthopedic practice. Most clinical and research efforts focus on restoring the damaged cartilage in connection with osteoarthritis or trauma. This article explains the current...
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Recent Advances in Three-Dimensional Multicellular Spheroid Formation for Biomedical Research

Park JH

Multicellular spheroids (MCSs) from three dimensional culture, which is a complex architectural structure with dynamic cell to cell and cell to matrix interactions, mimic real tissues regarding structural and functional...
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Evaluation of Collagen Gel-Associated Human Nasal Septum- Derived Chondrocytes As a Clinically Applicable Injectable Therapeutic Agent for Cartilage Repair

Lim MH, Jeun JH, Kim DH, Park SH, Kim SJ, Lee WS, Hwang SH, Lim JY, Kim SW

BACKGROUND: Articular cartilage injury has a poor repair ability and limited regeneration capacity with therapy based on articular chondrocytes (ACs) implantation. Here, we validated the hypothesis that human nasal septum-derived...
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Retinal Tissue Bioengineering, Materials and Methods for the Treatment of Glaucoma

Behtaj S, O¨ chsner A, Anissimov YG, Rybachuk M

BACKGROUND: Glaucoma, a characteristic type of optic nerve degeneration in the posterior pole of the eye, is a common cause of irreversible vision loss and the second leading cause of...
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Channeling Effect and Tissue Morphology in a Perfusion Bioreactor Imaged by X-Ray Microtomography

Beauchesne CC, Chabanon M, Smaniotto B, Ladoux B, Goyeau B, David B

BACKGROUND: Perfusion bioreactors for tissue engineering hold great promises. Indeed, the perfusion of culture medium enhances species transport and mechanically stimulates the cells, thereby increasing cell proliferation and tissue formation....
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In Vivo Bioreactor Using Cellulose Membrane Benefit Engineering Cartilage by Improving the Chondrogenesis and Modulating the Immune Response

Li XG, Park IS, Choi BH, Kim UJ, Min BH

BACKGROUND: To regenerate tissue-engineered cartilage as a source of material for the restoration of cartilage defects, we used a human fetal cartilage progenitor cell pellet to improve chondrogenesis and modulation...
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Chitosan-Hydroxyapatite Scaffold for Tissue Engineering in Experimental Lumbar Laminectomy and Posterolateral Spinal Fusion in Wistar Rats

Rodríguez-Vázquez M, Ramos-Zúñiga R

Study Design: Experimental study with an animal model. Purpose: To evaluate the role of a chitosan and hydroxyapatite composite for spinal fusion in a lumbar experimental model based on regenerative tissue...
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