Korean J Parasitol.  2013 Aug;51(4):421-426. 10.3347/kjp.2013.51.4.421.

Influence of Toxoplasma gondii Acute Infection on Cholinesterase Activities of Wistar Rats

Affiliations
  • 1Department of Small Animal, Universidade Federal de Santa Maria, Brazil. tonin.aat@gmail.com
  • 2Department of Animal Science, Universidade do Estado de Santa Catarina, Brazil.
  • 3Department of Microbiology and Parasitology, Universidade Federal de Santa Maria, Brazil.
  • 4Universidade Luteranda do Brasil-ULBRA. Santa Maria, Brazil.
  • 5Department of Preventive Veterinary Medicine, Universidade Federal de Santa Maria, Brazil.

Abstract

Several studies have shown the mechanisms and importance of immune responses against Toxoplasma gondii infection and the notable role of cholinesterases in inflammatory reactions. However, the association between those factors has not yet been investigated. Therefore, the aim of this study was to evaluate the acetylcholinesterase (AChE) activity in blood and lymphocytes and the activity of butyrylcholinesterase (BChE) in serum of rats experimentally infected with T. gondii during the acute phase of infection. For that, an in vivo study was performed with evaluations of AChE and BChE activities on days 5 and 10 post-infection (PI). The activity of AChE in blood was increased on day 5 PI, while in lymphocytes its activity was enhanced on days 5 and 10 PI (P<0.05). No significant difference was observed between groups regarding to the activity of BChE in serum. A positive (P<0.01) correlation was observed between AChE activity and number of lymphocytes. The role of AChE as an inflammatory marker is well known in different pathologies; thus, our results lead to the hypothesis that AChE has an important role in modulation of early immune responses against T. gondii infection.

Keyword

Toxoplasma gondii; acute toxoplasmosis; acetylcholinesterase (AchE); butyrylcholinesterase (BchE)
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