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Seroprevalence of Toxoplasma gondii in cats in mainland China 2016–2020: a meta-analysis

Zhou S, Sang Z, Wang L, Zhang T

Background: Toxoplasma gondii can infect humans and most animals and has a very high infection rate worldwide, including in China. The number of people infected with T. gondii in China...
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Toxoplasma gondii virulence prediction using hierarchical cluster analysis based on coding sequences (CDS) of sag1, gra7 and rop18

Subekti DT, Ekawasti F, Desem MI, Azmi Z

Toxoplasma gondii consists of three genotypes, namely genotype I, II and III. Based on its virulence, T. gondii can be divided into virulent and avirulent strains. This study intends to...
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Immunoinformatic analysis of immunogenic B- and T-cell epitopes of MIC4 protein to designing a vaccine candidate against Toxoplasma gondii through an in-silico approach

Ghaffari AD, Dalimi A, Ghaffarifar F, Pirestani M, Majidiani H

Purpose: Toxoplasmosis, transmitted by Toxoplasma gondii, is a worldwide parasitic disease that affects approximately one-third of the world’s inhabitants. Today, there are no appropriate drugs to deter tissue cysts from...
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Antigenic properties of dense granule antigen 12 protein using bioinformatics tools in order to improve vaccine design against Toxoplasma gondii

Ghaffari AD, Dalimi A, Ghaffarifar F, Pirestani M

Purpose: Toxoplasma gondii is an opportunistic parasite infecting all warm-blooded animals including humans. The dense granule antigens (GRAs) play an important role in parasite survival and virulence and in forming...
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Excretion of Toxoplasma gondii oocysts from Feral Cats in Korea

Ahn KS, Ahn AJ, Park SI, Sohn WM, Shim JH, Shin SS

Sporulated oocysts from the feces of infected cats with Toxoplasma gondii can cause detrimental disease in both humans and animals. To investigate the prevalence of feral cats that excrete T....
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Virus-like Particle Vaccine Containing Toxoplasma gondii Rhoptry Protein 13 Induces Protection against T. gondii ME49 Infection in Mice

Kang HJ, Chu KB, Lee SH, Kim MJ, Park H, Jin H, Quan FS

Toxoplasma gondii can infect humans worldwide, causing serious diseases in pregnant women and immunocompromised individuals. T. gondii rhoptry protein 13 (ROP13) is known as one of the key proteins involved...
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Parasite Infiltration and Apoptosis in Spleen upon Toxoplasma gondii Infection

Lee SH, Chu KB, Quan FS

Toxoplasma gondii infection induces parasite infiltration and apoptosis in the spleen. However, dose-dependent parasite infiltration, apoptosis, body weight alternations and survival in mice remain largely unknown. In this study, mice...
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Fulminant Toxoplasmic Chorioretinitis Following Intravitreal Dexamethasone Implantation

Jeong A, Park DG, Sagong M

PURPOSE: To report a case of fulminant toxoplasmic chorioretinitis following intravitreal dexamethasone implantation monotherapy in a stabilized toxoplasmic chorioretinitis patient with initial treatment. CASE SUMMARY: A 60-year-old healthy female presented with...
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Tracking acute phase protein response during acute and chronic Toxoplasma gondii infection

Atmaca HT, Gazyagci A, Terzi OS, Dincel GC, Sumer T

Toxoplasmosis is a disease caused by the protozoan Toxoplasma gondii, which occurs worldwide in mammals and birds. Brain is the primary target organ because Toxoplasma gondii is a ubiquitous intracellular...
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Seroprevalence of Toxoplasma gondii among School Children in Pyin Oo Lwin and Naung Cho, Upper Myanmar

Thái TL, Jun H, Park SH, Lê HG, Lee J, Ahn SK, Kang JM, Myint MK, Lin K, Sohn WM, Nam HW, Na BK, Kim TS

Toxoplasma gondii is an apicomplexan parasite that can cause toxoplasmosis in a wide range of warm-blooded animals including humans. In this study, we analyzed seroprevalence of T. gondii among 467...
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Production of Inflammatory Cytokines and Nitric Oxide by Human Mast Cells Incubated with Toxoplasma gondii Lysate

Park EA, Han IH, Kim JH, Park SJ, Ryu JS, Ahn MH

The roles of mast cells in allergic diseases and helminth infections are well known. However, the roles of mast cells in T. gondii infection is poorly understood. This study was...
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Previous Infection with Plasmodium berghei Confers Resistance to Toxoplasma gondii Infection in Mice

Lee DH, Chu KB, Kang HJ, Lee SH, Quan FS

Both Plasmodium spp. and Toxoplasma gondii are important apicomplexan parasites, which infect humans worldwide. Genetic analyses have revealed that 33% of amino acid sequences of inner membrane complex from the...
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Rhoptry antigens as Toxoplasma gondii vaccine target

Foroutan M, Ghaffarifar F, Sharifi Z, Dalimi A, Jorjani O

Toxoplasmosis is a cosmopolitan zoonotic infection, caused by a unicellular protozoan parasite known as Toxoplasma gondii that belongs to the phylum Apicomplexa. It is estimated that over one-third of the...
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Tissue Fluid Enzyme-Linked Immunosorbant Assay for Piglets Experimentally Infected with Toxoplasma gondii and Survey on Local and Imported Pork in Korean Retail Meat Markets

Yoo WG, Kim SM, Won EJ, Lee JY, Dai F, Woo HC, Nam HW, Kim TI, Han JH, Kwak D, Cho YS, Kang SW, Kim TS, Zhu XQ, Wang C, Youn H, Hong SJ

To investigate the prevalence of Toxoplasma gondii in pork on the market in Korea, an in-house enzyme-linked immunosorbent assay for tissue fluid (CAU-tf-ELISA) was developed using a soluble extract of...
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Virus-Like Particles Expressing Toxoplasma gondii Rhoptry Protein 18 Induces Better Protection Than Rhoptry Protein 4 against T. gondii Infection

Kang HJ, Lee SH, Chu KB, Lee DH, Quan FS

Toxoplasma gondii is a ubiquitous protozoan parasite responsible for causing toxoplasmosis. Preventive measures for toxoplasmosis are currently lacking and as such, development of novel vaccines are of urgent need. In...
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Evaluation of Protective Immune Response Induced by a DNA Vaccine Encoding GRA8 against Acute Toxoplasmosis in a Murine Model

Chu JQ, Huang S, Ye W, Fan XY, Huang R, Ye SC, Yu CY, Wu WY, Zhou Y, Zhou W, Lee YH, Quan JH

Toxoplasma gondii is an apicomplexan zoonotic protozoan parasite that infects most species of warm-blooded animals, including humans. The heavy incidence and severe or lethal damage caused by T. gondii infection...
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Recent progress in microneme-based vaccines development against Toxoplasma gondii

Foroutan M, Zaki L, Ghaffarifar F

Toxoplasmosis is a cosmopolitan zoonotic disease, which infect several warm-blooded mammals. More than one-third of the human population are seropositive worldwide. Due to the high seroprevalence of Toxoplasma gondii infection...
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Immune Responses Induced by HSP60 DNA Vaccine against Toxoplasma gondii Infection in Kunming Mice

Li ZY, Lu J, Zhang NZ, Chen J, Zhu XQ

Toxoplasma gondii can infect all the vertebrates including human, and leads to serious toxoplasmosis and considerable veterinary problems. T. gondii heat shock protein 60 (HSP60) is associated with the activation...
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Serologic Tests of IgG and IgM Antibodies and IgG Avidity for Diagnosis of Ocular Toxoplasmosis

Rahimi-Esboei B, Zarei M, Mohebali M, Valian HK, Shojaee S, Mahmoudzadeh R, Salabati M

This prospective study was aimed to detect acute and chronic ocular toxoplasmosis by comparison of anti-Toxoplasma gondii IgM and IgG antibody levels and IgG avidity test. One hundred and seventeen...
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Modulated Gene Expression of Toxoplasma gondii Infected Retinal Pigment Epithelial Cell Line (ARPE-19) via PI3K/Akt or mTOR Signal Pathway

Zhou W, Quan JH, Gao FF, Ismail HA, Lee YH, Cha GH

Due to the critical location and physiological activities of the retinal pigment epithelial (RPE) cell, it is constantly subjected to contact with various infectious agents and inflammatory mediators. However, little...
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