J Korean Med Sci.  2006 Dec;21(6):1075-1079. 10.3346/jkms.2006.21.6.1075.

Association of the GSTP1 and NQO1 Polymorphisms and Head and Neck Squamous Cell Carcinoma Risk

• Cho CG
• Lee SK
• Nam SY
• Lee MS
• Lee SW
• Choi EK
• Park HJ
• Kim SY

• KMID: 1713122
• DOI: http://doi.org/10.3346/jkms.2006.21.6.1075

Abstract

The GSTP1 and NQO1 have been reported to be associated with an increased risk for smoking related head and neck squamous cell carcinoma (HNSCC). The purpose of this study was to determine the effect of these metabolic gene polymorphisms on the risk of HNSCC. The study population included 294 histologically confirmed HNSCC cases and 333 controls without cancer. Genotyping analysis of the GSTP1 Ile105Val and NQO1 Trp139Arg genes was performed by polymerase chain reaction-based techniques on DNA prepared from peripheral blood. The Mantel-Haenszel chi-square test was used for statistical analysis. The allele frequencies of the GSTP1 and NQO1 polymorphisms were not statistically significant between cases and controls. In analyzing the association between smoking amounts and genetic polymorphisms, GSTP1 and NQO1 polymorphisms were associated with cigarette smoking amounts in cases. G allele containing genotypes in GSTP1 and T allele containing genotypes in NQO1 were associated with a tobacco dose-dependent increase in risk of HNSCC and these genotype distributions were statistically significant (p<0.05). We found that the GSTP1 105Val allele and NQO1 139Arg allele were associated with tobacco dose-dependent increase in risk of HNSCC. GSTP1 and NQO1 genotype polymorphisms may play an important role in the development of smoking related HNSCC.

Keyword

Glutathione S-Transferase pi; NADH dehydrogenase (quinone); Head and Neck Neoplasms; Carcinoma, Squamous Cell; Smoking

MeSH Terms

Smoking/*epidemiology
Risk Factors
Risk Assessment/methods
Prevalence
Polymorphism, Single Nucleotide/genetics
NAD(P)H Dehydrogenase (Quinone)/*genetics
Middle Aged
Male
Korea/epidemiology
Humans
Head and Neck Neoplasms/*epidemiology/*genetics
Glutathione S-Transferase pi/*genetics
Genetic Predisposition to Disease/genetics
DNA Mutational Analysis
Carcinoma, Squamous Cell/*epidemiology/*genetics
Aged, 80 and over
Aged
Adult

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