Korean Circ J.  1987 Dec;17(4):789-794. 10.4070/kcj.1987.17.4.789.

Clinical Trial on the Hypotensive Effect of Carteolol

• Yoo DH
• Shin CR
• Ahn MJ
• Kim JH
• Lim HK
• Lee BH
• Lee CK

• KMID: 1668920
• DOI: http://doi.org/10.4070/kcj.1987.17.4.789

Abstract

The clinical trial was carried out with carteolol in 30 patients with essential hypertension. The results were as follows : 1) Before medication and after 2,4,6 and 8 weeks of medications, the overall average systolic and diastolic blood pressure were 175+/-17.7/105+/-9.3, 144+/-8.9/92+/-6.9, 143+/-11.2/90+/-6.6, 141+/-8.4/88+/-6.9, and 142+/-9.0/88+/-7.1 mmHg. As a result, blood pressure significantly fell with carteolol treatment. 2) In 80+/- of all cases, marked or moderate degree of hypotnesive effect was observed within 2 weeks of treatment. 3) Before medication and after 2, 4, 6 and 8 weeks of medication, the overall average heart rates were 75+/-11.8, 73+/-9.0, 71+/-8.7, 71+/-8.2 and 71+/-8.6 beats/minute. There was no significant changes in heart rates before and after treatment. 4) Dizziness or fatigability were complained in 4 patients (13+/-) each while receiving carteolol. These side effects were mild in 3 patients, but one patient discontinued treatment due to dizziness. On the basis of these results, carteolol was evaluated to be promising hypotensive drug.

MeSH Terms

Blood Pressure
Carteolol*
Dizziness
Heart Rate
Humans
Hypertension
Carteolol