J Korean Ophthalmol Soc.  1987 Feb;28(1):111-115.

Hypetensive Effect of Carteolol Hydrochloride(Mikelan(R)) In Normal Volunteers: Comparative Study with Timolol

Affiliations
  • 1Department of Ophthalmology, Capital Armed Forces General Hospital, Seoul, Korea.
  • 2Dr. Hong's Eye Clinic, Seoul, Korea.

Abstract

Carteolol hydrochloride was compared with Timolol in view of the hypotensive effect. Forty-five normal volunteers(90 eyes) of the third decade were evaluated. Forty volunteers of experimental group were devided into two groups, -Carteolol group and Timolol one-. Carteolol group was subdevided into 1% and 2% group and Timolol one was subgrouped into 0.25% and 0.5% group, respectively. The remaining five volunteers(10 eyes) were used as control group. Double masked single dose study was done by instilling each eye solution into the one eye selected randomly. The intraocular pressure, pupil size, visual acuity, blood pressure, and pulse rate were measured before the instillation of eye solution at first and 30 minutes, 1, 2, 4, 6, and 24 hours after instillation and the statistical significance was estimated using the paired t-test. The following results were obtained: 1. In both groups of 1% and 2% Carteolol, the IOP reduction was noted since 1 hour after instillation and each maximum reduction of IOP was noted at 4 hours after instillation (29.2 +/- 5.0%, 40.4 +/- 5.0%, respectively). Instillation of higher concentrations of Carteolol and Timolol resulted in more significant pressure reduction. 2. Statistically significant IOP reduction was also noted in the contralateral eyes in each group. 3. The pupil size, visual acuity, blood pressure, and pulse rate were not significantly changed after the instillation of Carteolol ophthalmic solution and no remarkable local complication were also noted.


MeSH Terms

Blood Pressure
Carteolol*
Healthy Volunteers*
Heart Rate
Intraocular Pressure
Masks
Pupil
Timolol*
Visual Acuity
Volunteers
Carteolol
Timolol
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