Korean J Urol.  1995 Apr;36(4):359-367.

The Prognostic Significance of Silver-Binding Nucleolar Organizer Regions, Proliferating Cell Nuclear Antigen and Flow Cytometric DNA Analysis in Superficial Bladder Tumors

• Park JS
• Chung MK

Abstract

The proliferating activity of the cancer cells was estimated in 67 superficial bladder tumors (26 pTa and 41 pT1) by the silver-binding nucleolar organizer regions(AgNORs), proliferating cell nuclear antigen(PCNA) and flow cytometric DNA analysis. the clinical variances, AgNORs count, PCNA positivity and the incidence of aneuploidy showed no correlation with recurrence statistically. But cytology, grade and PCNA positivity had statistical significance for progression (p<0.0.05). Especially cytology and PCNA positivity showed independent predictive values in multiple logistic regression analysis. We analyzed the values with above mentioned method including intravesical chemotherapy. None of above showed correlation with recurrence statistically. Cytology, grade, BCG therapy and PCNA positivity had statistical significance for progression( p <0.05). But none of those showed statistical significance in multiple logistic regression analysis. In summary, AgNORs count, PCNA positivity and the incidence of aneup1oidy may not have the value of prognostic factor to predict recurrence and/or progression if include intravesical chemotherapy.

Keyword

Superficial transitional cell carcinoma; AgNORs; PCNA; Flowcytometry

MeSH Terms

Aneuploidy
DNA*
Drug Therapy
Incidence
Logistic Models
Mycobacterium bovis
Nucleolus Organizer Region*
Proliferating Cell Nuclear Antigen*
Recurrence
Urinary Bladder Neoplasms*
Urinary Bladder*
DNA
Proliferating Cell Nuclear Antigen