J Korean Ophthalmol Soc.  1972 Sep;13(3):107-119.

Studies on the Phosphorylase Activity in Ciliary Muscle

• Lee SH

Abstract

The author studied the effects of adrenergic and its blocking agents, ACTH, methylprednisolone, 5-hydroxytryptamine, and prostaglandin E1 and E2 on the phosphorylase activity in bovine ciliary muscle in vitro and obtained the following results. 1. The phosphorylase activity in bovine ciliary muscle was enhanced by the adrenergic agents. such as epinephrine. norepinephrine and isoproterenol, but was not affected by adrenergic alpha receptor blocking agents, such as phenoxybenzamine and phentolamine, and adrenergic beta receptor blockades. such as propranolol and pronethalol. Pretreatment with propranolol prevented partly the epinephrine-induced increase of the phosphorylase activity in bovine ciliary muscle. 2. The phosphorylase activity in bovine ciliary muscle was shown to be stimulated by ACTH, methylprednisolone and 5-hydroxytryptamine but not by prostaglandin E1 and E2. 3. The phosphorylase activity in bovine ciliary muscle which was stimulated by epinephrine, ACTH, methylprednisolone or 5-hydroxytryptamine was markedly blocked by pretreatment with prost aglandin E1 but less by prostaglandin E2. 4. Prostaglandin E1 exerted no effects on the phosphorylase activity in bovine ciliary muscle following the addition of cyclic AMP or MgH++-ATP, but markedly depressed that stimulated by epinephrine.

MeSH Terms

Adrenergic Agents
Adrenocorticotropic Hormone
Alprostadil
Cyclic AMP
Dinoprostone
Epinephrine
Isoproterenol
Methylprednisolone
Norepinephrine
Phenoxybenzamine
Phentolamine
Propranolol
Serotonin
Zygote Intrafallopian Transfer
Adrenergic Agents
Adrenocorticotropic Hormone
Alprostadil
Cyclic AMP
Dinoprostone
Epinephrine
Isoproterenol
Methylprednisolone
Norepinephrine
Phenoxybenzamine
Phentolamine
Propranolol
Serotonin