- Tryptophan Metabolites in Irritable Bowel Syndrome: An Overnight Time-course Study
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Burr RL, Gu H, Cain K, Djukovic D, Zhang X, Han C, Callan N, Raftery D, Heitkemper M
- KMID: 2460485
- J Neurogastroenterol Motil.
- 2019 Oct;25(4):551-562.
- doi: 10.5056/jnm19042
BACKGROUND/AIMS: Patients with irritable bowel syndrome (IBS) often report poor sleep quality. Whether poor sleep is associated with tryptophan (Trp) metabolites is unknown. We compared serum Trp metabolites in women... -
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- Effects of Oxytocin on Cell Proliferation in a Corticotroph Adenoma Cell Line
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Lim JS, Eom YW, Lee ES, Kwon HJ, Kwon JY, Choi J, Chung CH, Jo YS, Lee EJ
- KMID: 2458633
- Endocrinol Metab.
- 2019 Sep;34(3):302-313.
- doi: 10.3803/EnM.2019.34.3.302
BACKGROUND: Oxytocin (OXT) has been reported to act as a growth regulator in various tumor cells. However, there is a paucity of data on the influence of OXT on cell... -
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- Impaired Cortisol and Growth Hormone Counterregulatory Responses among Severe Hypoglycemic Patients with Type 2 Diabetes Mellitus
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Rhyu YA, Jang JY, Park S, An JH, Kim DL, Kim SK, Song KH
- KMID: 2450519
- Endocrinol Metab.
- 2019 Jun;34(2):187-194.
- doi: 10.3803/EnM.2019.34.2.187
BACKGROUND: Elevated levels of cortisol and growth hormone are critical counterregulatory responses to severe hypoglycemia. However, the proportion and clinical characteristics of patients with type 2 diabetes mellitus (DM) who... -
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- Prognostic Implication of Adrenocortical Response during the Course of Critical Illness
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Song JH, Kim JH, Lee SM, Lee J
- KMID: 2449378
- Acute Crit Care.
- 2019 Feb;34(1):38-45.
- doi: 10.4266/acc.2018.00339
BACKGROUND: Critical illness-related corticosteroid insufficiency (CIRCI) and adrenocorticotropic hormone (ACTH)-cortisol dissociation are hormonal conditions frequently observed in patients in the intensive care unit (ICU). The aim of this study was... -
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- Prevalence of CYP17A1 gene mutations in 17α-hydroxylase deficiency in the Chinese Han population
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Wang M, Wang H, Zhao H, Li L, Liu M, Liu F, Meng F, Fan C
- KMID: 2468629
- Clin Hypertens.
- 2019 ;25(1):23.
- doi: 10.1186/s40885-019-0128-6
BACKGROUND: 17α-hydroxylase deficiency is a rare autosomal recessive disorder caused by mutations in the cytochrome P450 family 17 subfamily A member 1 gene. The major clinical presentation includes hypertension, hypokalemia,... -
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- Clinical Significance of Radical Surgery in the Treatment of Silent Corticotroph Adenoma
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Kim J, Yoon SJ, Moon JH, Ku CR, Kim SH, Lee EJ, Kim SH, Kim EH
- KMID: 2434353
- J Korean Neurosurg Soc.
- 2019 Jan;62(1):114-122.
- doi: 10.3340/jkns.2018.0027
OBJECTIVE: Silent corticotroph adenomas (SCA) are endocrine-inactive pituitary adenomas with positive immunohistochemistry staining for adrenocorticotropic hormone (ACTH). We investigated whether SCA-associated clinical profiles were more aggressive than hormonally negative adenomas... -
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- Compound heterozygosity for a whole gene deletion and p.R124C mutation in CYP21A2 causing nonclassic congenital adrenal hyperplasia
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Nasir H, Ali SI, Haque N, Grebe SK, Kirmani S
- KMID: 2422481
- Ann Pediatr Endocrinol Metab.
- 2018 Sep;23(3):158-161.
- doi: 10.6065/apem.2018.23.3.158
We present a family with 2 members who received long-term steroid treatment for presumed classic congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency, until molecular testing revealed nonclassic CAH, not... -
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- Recent Updates on the Diagnosis and Management of Cushing's Syndrome
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Nieman LK
- KMID: 2420480
- Endocrinol Metab.
- 2018 Jun;33(2):139-146.
- doi: 10.3803/EnM.2018.33.2.139
Cushing's syndrome, a potentially lethal disorder characterized by endogenous hypercortisolism, may be difficult to recognize, especially when it is mild and the presenting features are common in the general population.... -
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- Characteristics of Adrenal Incidentalomas in a Large, Prospective Computed Tomography-Based Multicenter Study: The COAR Study in Korea
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Ahn SH, Kim JH, Baek SH, Kim H, Cho YY, Suh S, Kim BJ, Hong S, Koh JM, Lee SH, Song KH
- KMID: 2410905
- Yonsei Med J.
- 2018 Jun;59(4):501-510.
- doi: 10.3349/ymj.2018.59.4.501
PURPOSE: Previous studies on adrenal incidentalomas (AIs) are limited by their retrospective design, small numbers of patients, Western populations, or use of an outdated imaging technique. We investigated the characteristics... -
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- Critical Illness-Related Corticosteroid Insufficiency in Patients with Low Cardiac Output Syndrome after Cardiac Surgery
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Ok YJ, Lim JY, Jung SH
- KMID: 2409694
- Korean J Thorac Cardiovasc Surg.
- 2018 Apr;51(2):109-113.
- doi: 10.5090/kjtcs.2018.51.2.109
BACKGROUND: Low cardiac output syndrome (LCOS) after cardiac surgery usually requires inotropes. In this setting, critical illness-related corticosteroid insufficiency (CIRCI) may develop. We aimed to investigate the clinical features of... -
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- Associations Among Plasma Stress Markers and Symptoms of Anxiety and Depression in Patients with Breast Cancer Following Surgery
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Ju HB, Kang EC, Jeon DW, Kim TH, Moon JJ, Kim SJ, Choi JM, Jung DU
- KMID: 2409421
- Psychiatry Investig.
- 2018 Feb;15(2):133-140.
- doi: 10.30773/pi.2017.07.26
OBJECTIVE: The objective of present study is to analyze the prevalence of depression and anxiety following breast cancer surgery and to assess the factors that affect postoperative psychological symptoms. METHODS: The... -
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- Histone deacetylase inhibition attenuates hepatic steatosis in rats with experimental Cushing's syndrome
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Kim M, Lee HA, Cho HM, Kang SH, Lee E, Kim IK
- KMID: 2398552
- Korean J Physiol Pharmacol.
- 2018 Jan;22(1):23-33.
- doi: 10.4196/kjpp.2018.22.1.23
Cushing's syndrome (CS) is a collection of symptoms caused by prolonged exposure to excess cortisol. Chronically elevated glucocorticoid (GC) levels contribute to hepatic steatosis. We hypothesized that histone deacetylase inhibitors... -
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- Corticosteroid Treatment in Critically Ill Patients
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Lee S, Ryu JA
- KMID: 2405762
- J Neurocrit Care.
- 2017 Dec;10(2):86-91.
- doi: 10.18700/jnc.170030
Increased levels of tissue corticosteroids are associated with important protective responses of critically ill patients. Critical illness and its treatment interfere with the normal corticosteroid response to illness and induce... -
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- Intravenous Corticotropin-releasing Hormone Administration Increases Esophageal Electrical Sensitivity in Healthy Individuals
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Yamasaki T, Tomita T, Takimoto M, Kondo T, Tozawa K, Ohda Y, Oshima T, Fukui H, Watari J, Miwa H
- KMID: 2395420
- J Neurogastroenterol Motil.
- 2017 Oct;23(4):526-532.
- doi: 10.5056/jnm17067
BACKGROUND/AIMS: When a person is experiencing stress, corticotropin-releasing hormone (CRH) can modulate gut physiologies, such as visceral sensation or gastrointestinal motility, and its intravenous administration mimics stress-induced physiological changes. However,... -
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- Clinical Characteristics of Patients with Adrenal Insufficiency in a General Hospital
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Lee YY, Cho NH, Lee JW, Kim NK, Kim HS, Kim MK
- KMID: 2413291
- Endocrinol Metab.
- 2017 Mar;32(1):83-89.
- doi: 10.3803/EnM.2017.32.1.83
BACKGROUND: Adrenal insufficiency (AI) is a life-threatening disorder caused by the deficiency of adrenal steroid hormones. This retrospective cross-sectional study investigated the characteristics of patients with AI in Korea. METHODS: All... -
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- ACTH-producing neuroendocrine tumor of the pancreas: a case report and literature review
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Byun J, Kim SH, Jeong HS, Rhee Y, Lee WJ, Kang CM
- KMID: 2371570
- Ann Hepatobiliary Pancreat Surg.
- 2017 Feb;21(1):61-65.
- doi: 10.14701/ahbps.2017.21.1.61
Tumors that arise from the endocrine pancreas, or the islets of pancreas, are called pancreatic neuroendocrine tumors (NETs). Pancreatic NET have an incidence of -
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- The Recovery of Hypothalamic-Pituitary-Adrenal Axis Is Rapid in Subclinical Cushing Syndrome
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Kim HK, Yoon JH, Jeong YA, Kang HC
- KMID: 2373080
- Endocrinol Metab.
- 2016 Dec;31(4):592-597.
- doi: 10.3803/EnM.2016.31.4.592
BACKGROUND: In subclinical Cushing syndrome (SC), it is assumed that glucocorticoid production is insufficient to cause a clinically recognizable syndrome. Differences in hormonal levels or recovery time of the hypothalamic-pituitary-adrenocortical... -
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- Large-Dose Glucocorticoid Induced Secondary Adrenal Insufficiency in Spinal Cord Injury
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Park SH, Cho KH
- KMID: 2371335
- Ann Rehabil Med.
- 2016 Dec;40(6):1033-1039.
- doi: 10.5535/arm.2016.40.6.1033
OBJECTIVE: To investigate the incidence of adrenal insufficiency (AI) in patients with spinal cord injury (SCI) with symptoms similar to those of AI and to assess the relevance of AI... -
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- Secondary adrenal insufficiency caused by sorafenib administration in a patient with hepatocellular carcinoma
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Jo SY, Ryu SH, Kim MY, Moon JS, Yoon WJ, Kim JN
- KMID: 2366131
- Yeungnam Univ J Med.
- 2016 Dec;33(2):155-158.
- doi: 10.12701/yujm.2016.33.2.155
Sorafenib (Nexavar) has been regarded as a treatment for unresectable hepatocellular carcinoma (HCC), with side effects that include hand-foot skin reaction, diarrhea, rash, fatigue, hypertension, nausea, anorexia, weight loss, and... -
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- Dai-Kenchu-To, a Herbal Medicine, Attenuates Colorectal Distention-induced Visceromotor Responses in Rats
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Nakaya K, Nagura Y, Hasegawa R, Ito H, Fukudo S
- KMID: 2433462
- J Neurogastroenterol Motil.
- 2016 Oct;22(4):686-693.
- doi: 10.5056/jnm15190
BACKGROUND/AIMS: Dai-kenchu-to (DKT), a traditional Japanese herbal medicine, is known to increase gastrointestinal motility and improve ileal function. We tested our hypotheses that (1) pretreatment with DKT would block the... -
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