J Korean Ophthalmol Soc.  1972 Mar;13(1):11-16.

The effects of adrenergic and adrenergic blocking agents on the phosphorylase activity of bovine extraocular muscles

• Pak BG

Abstract

The author investigated the effect of adrenergic and adrenergic blocking agents on the phosphorylase activity of bovine extraocular muscle in vitro and obtained the following results: 1. The phosphorylase a activity of bovine extraocular muscle was revealed 53.6% in vitro. 2. The phosphorylase a activity of bovine extraocular muscle was slightly enhanced by the adrenergic agents such as epinephrine, norepinephrine and isoproterenol. 3. The phosphorylase a activity of bovine extraocular muscle was not affected by the adrenergic areceptor blocking agent, phenoxybenzamine but slightly inhibited by the adrenergic beta-receptor blocking agent, propranolol. 4. The phosphorylase a activity of bovine extraocular muscle previously treated with the adrenergic agents was blocked by a sole administration of propranolol or combined administrations of propranolol and phenoxybenzamine but not blocked by phenoxybenzamine alene.

MeSH Terms

Adrenergic Agents
Adrenergic Antagonists*
Epinephrine
Isoproterenol
Muscles*
Norepinephrine
Phenoxybenzamine
Phosphorylase a
Propranolol
Adrenergic Agents
Adrenergic Antagonists
Epinephrine
Isoproterenol
Norepinephrine
Phenoxybenzamine
Phosphorylase a
Propranolol