Korean J Hematol.  2005 Sep;40(3):197-200. 10.5045/kjh.2005.40.3.197.

A Pediatric Case with CMV Gastroenteritis after Donor Leukocyte Infusion

• Song AK
• Kim HJ
• Jung HJ
• Park JE
• Jeong IH
• Park JS
• Kim HC

• KMID: 1610816
• DOI: http://doi.org/10.5045/kjh.2005.40.3.197

Abstract

There haves been few reports of cytomegalovirus (CMV) gastroenteritis following allogeneic stem cell transplantation, especially in pediatric cases. Herein, we report a case of CMV gastroenteritis in a 10-year-old boy with relapsed juvenile myelomonocytic leukemia who had undergone a donor leukocyte infusion. He presented with a skin rash, diarrhea and abdominal pain following a donor leukocyte infusion. Cramping abdominal pain persisted, even after treatment of the acute graft-versus-host disease. Therefore, gastroduodenoscopy and a gastric mucosal biopsy were performed, after which CMV gastroenteritis was diagnosed. The boy recovered after treatment with ganciclovir and intravenous immunoglobulin.

Keyword

CMV gastroenteritis; GVHD; Donor leukocyte infusion

MeSH Terms

Abdominal Pain
Biopsy
Child
Cytomegalovirus
Diarrhea
Exanthema
Ganciclovir
Gastroenteritis*
Graft vs Host Disease
Humans
Immunoglobulins
Leukemia, Myelomonocytic, Juvenile
Leukocytes*
Male
Muscle Cramp
Stem Cell Transplantation
Tissue Donors*
Ganciclovir
Immunoglobulins

Figure

• 

  Fig. 1. Gastroduodenoscopic finding. The duodenal mucosa showed multiple erosions with patchy hyperemia.

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  Fig. 2. The brownish-red cytomegalic cells (arrowed) showed the positive reactivity in both cytoplasm and nucleus by immunoperoxidase staining for cytomegalovirus (× 100).

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