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Analysis of differences in human leukocyte antigen between the two Wellcome Trust Case Control Consortium control datasets

Jang CS, Choi W, Cook S, Han B

The Wellcome Trust Case Control Consortium (WTCCC) study was a large genome-wide association study that aimed to identify common variants associated with seven diseases. That study combined two control datasets...
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Comparison of Red Blood Cell, White Blood Cell and Differential Counts between UF-5000 System and Manual Method

Koo MS, Lim J, Kim SY, Koo SH, Kwon GC

BACKGROUND: Analysis of body fluids provides important information for assessing various medical conditions. We aimed to validate the analytical and diagnostic performance of the Sysmex UF-5000 (Sysmex, Japan) system for...
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Human leukocyte antigen-associated severe cutaneous adverse drug reactions: from bedside to bench and beyond

Nguyen DV, Vidal C, Chu HC, van Nunen

Despite their being uncommon, severe cutaneous adverse drug reactions (SCARs) result in a very great burden of disease. These reactions not only carry with them a high mortality (10%–50%) and...
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Validation of systemic inflammatory response syndrome criteria without white blood cell count in Korean Triage and Acuity Scale

Sun J, Chung H, Jang H, Kim S, Lee Y, Park J

OBJECTIVE: The systemic inflammatory response syndrome (SIRS) criteria used in the triage scale have been implemented incompletely without laboratory data, such as the white blood cell (WBC) count, so the...
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Two-photon intravital imaging of leukocyte migration during inflammation in the respiratory system

Kim YM, Jeong S, Choe YH, Hyun YM

Two-photon intravital imaging is a powerful method by which researchers are able to directly observe biological phenomena in live organisms. Researchers in various biomedical research fields have applied two-photon imaging...
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The Difference in Serum Ferritin and Leukocyte Regarding Overweight and Obese South Korean Adults

Lee HS

PURPOSE: The purpose of this study was to investigate the difference in serum ferritin and leukocyte regarding overweight and obese South Korean adults. METHODS: This study was conducted on 5,281 subjects...
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Leukocyte Telomere Length Reflects Prenatal Stress Exposure, But Does Not Predict Atopic Dermatitis Development at 1 Year

Suh DI, Kang MJ, Park YM, Lee JK, Lee SY, Sheen YH, Kim KW, Ahn K, Won HS, Lee MY, Choi SJ, Kwon JY, Park HJ, Jun JK, Hong SJ, Koh YY

PURPOSE: Prenatal maternal stress affects offspring's atopic dermatitis (AD) development, which is thought to be mediated by the oxidative stress. We aimed to evaluate the difference in leukocyte telomere length...
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Human Leukocyte Antigen Class I and Programmed Death-Ligand 1 Coexpression Is an Independent Poor Prognostic Factor in Adenocarcinoma of the Lung

Han YB, Kwon HJ, Park SY, Kim ES, Kim H, Chung JH

BACKGROUND: Both human leukocyte antigen (HLA) class I and programmed death-ligand 1 (PD-L1) molecules are known to play important roles in cancer immunity. In this study, we evaluated HLA class...
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Loss of Human Leukocyte Antigen Class I Expression Is Associated with Poor Prognosis in Patients with Advanced Breast Cancer

Park HS, Cho U, Im SY, Yoo CY, Jung JH, Suh YJ, Choi HJ

BACKGROUND: Human leukocyte antigen class I (HLA-I) molecules play important roles in regulating immune responses. Loss or reduction of HLA-I expression has been shown to be associated with prognosis in...
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Development of a Novel Flow Cytometry-Based System for White Blood Cell Differential Counts: 10-color LeukoDiff

Park D, Chang J, Kahng J, Park H, Jo I, Kim Y, Han K

BACKGROUND: Flow cytometry (FCM) is commonly used to identify many cell populations. We developed a white blood cell (WBC) differential counting system for detecting abnormal cells using FCM incorporating 10...
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Successful treatment of early acute antibody-mediated rejection in an human leukocyte antigen-incompatible and ABO-incompatible living-donor kidney transplant patient

Gang S, Han A, Min SI, Ha J, Yang J

For successful human leukocyte antigen-incompatible (HLAi) or ABO-incompatible (ABOi) living-donor kidney transplantations (LDKTs), pretransplant desensitization is essential; however, early antibody-mediated rejection (ABMR) remains the most important complication after HLAi or...
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Extremely high white blood cell counts on postoperative day 1 do not predict severe complications following distal pancreatectomy

Jung GH, Hwang HK, Lee WJ, Kang CM

BACKGROUNDS/AIMS: Distal pancreatectomy(DP) is associated with high morbidity. In clinical practice, postoperative white blood cell(WBC) counts are useful indicators of infection complications. The aim of this study was to determine...
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The risk of preschool asthma at 2–4 years is not associated with leukocyte telomere length at birth or at 1 year of age

Suh DI, Kang MJ, Park YM, Lee JK, Lee SY, Sheen YH, Kim KW, Ahn K, Hong SJ

BACKGROUND: Exposure to prenatal stress is associated with offspring allergic-disease development, and oxidative stress may mediate this relationship. OBJECTIVE: We aimed to evaluate whether leukocyte telomere length (LTL) shortening, a marker...
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Analysis of swine leukocyte antigen class I gene profiles and porcine endogenous retrovirus viremia level in a transgenic porcine herd inbred for xenotransplantation research

Matczyńska D, Sypniewski D, Gałka S, Sołtysik , Loch T, Nowak E, Smorąg Z, Bednarek I

Molecular characterization of swine leukocyte antigen (SLA) genes is important for elucidating the immune responses between swine-donor and human-recipient in xenotransplantation. Examination of associations between alleles of SLA class I...
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Association between White Blood Cell Counts within Normal Range and Hemoglobin A1c in a Korean Population

Hong JW, Noh JH, Kim DJ

BACKGROUND: We examined whether white blood cell (WBC) count levels within normal range, could be associated with hemoglobin A1c (HbA1c) levels. METHODS: Among the 11,472 people (≥19 years of age) who...
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Leukocyte Adhesion Deficiency Associated with Neonatal Septic Hip in a Late Preterm Infant

Kim HE, Kim DH, Chung SH, Bae CW, Choi YS

Leukocyte adhesion deficiency is a rare primary immunodeficiency and autosomal recessive disorder caused by a mutation in the gene encoding CD18, which is a constituent of leukocyte integrins. Clinical features...
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The White Blood Cell Count to Hemoglobin Level Ratio is Correlated with the Presence of Cortical Defects on DMSA Renal Scans in Children with Febrile Urinary Tract Infection

Jin BK, Baek KS, Rhie SK, Lee JH

PURPOSE: We investigated whether the white blood cell (WBC) count to hemoglobin (Hgb) level ratio is correlated with the presence of cortical defects on dimercaptosuccinic acid (DMSA) renal scan in...
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Decreased Expression of Sphingosine-1-Phosphate Receptor 1 in the Blood Leukocyte of Rheumatoid Arthritis Patients

Choi HS, Kim KH, Jin S, Kim J, Yoo I, Pack SP, Ha UH, Park TW, Choi SA, Yuk SH, Kang SW, Jung YW

Sphingosine-1-phosphate (S1P) plays an important role in trafficking leukocytes and developing immune disorders including autoimmunity. In the synovium of rheumatoid arthritis (RA) patients, increased expression of S1P was reported, and...
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Clinical significance of the presence of anti-human leukocyte antigen-donor specific antibody in kidney transplant recipients with allograft dysfunction

Chung BH, Kim JH, Choi BS, Park CW, Kim JI, Moon IS, Kim YS, Choi YJ, Oh EJ, Yang CW

BACKGROUND/AIMS: This study investigated the clinical significance of detecting anti-human leukocyte antigen-donor specific antibody (HLA-DSA) in kidney transplant recipients (KTRs) requiring indication biopsy owing to allograft dysfunction. METHODS: We analyzed the...
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Prevalence, Risk Factors, and Expression of Human Leukocyte Antigen-DRB1 in Juvenile Idiopathic Arthritis-associated Uveitis

Pyo JK, Lee S, Kim KN

OBJECTIVE: This study investigated the prevalence and risk factors of juvenile idiopathic arthritis (JIA)-associated uveitis (JIA-U) in a pediatric tertiary center in Korea. In addition, this study examined whether a...
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