A Case of Intestinal Pseudoobstruction with Positive Serum Anti - Hu Antibody in Small Cell Lung Carcinoma

Ye, Byong Duk; Park, Wan Bum; Lee, Jong Yeul; Kim, Ji Won; Kim, Byeong Gwan; Kim, Joo Sung; Jung, Hyun Chae; Song, In Sung

Abstract

Intestinal pseudoobstruction is a clinical syndrome presenting with symptoms and signs of intestinal obstruction without the evidence of a structural obstructing lesion. Recently, case reports have revealed an association between intestinal pseudoobstruction and various malignancies, especially small cell lung carcinoma. In the paraneoplastic intestinal pseudoobstruction associated with small cell lung carcinoma, anti-neuronal nuclear antibody called anti-Hu antibody was positive in most patients. This report describes a case of 53-year-old man who complained of diffuse, intermittent colicky abdominal pain, nausea, and vomiting. He was diagnosed as having syndrome of inappropriate ADH, intestinal pseudoobstruction, and small cell lung carcinoma. The presence of anti-Hu antibody in patient's serum supports the diagnosis of paraneoplastic intestinal pseudoobstruction associated with small cell lung carcinoma.