Korean Lepr Bull.  2005 Jun;38(1):15-24.

The Review of Epidemiological investigation of Leprosy by Using Polymerase Chain Reaction

Affiliations
  • 1Institute for Leprosy Research, Korean Hansen Welfare Association, Korea. dr_jpkim@hotmail.com

Abstract

Studies about Mycobacterium leprae DNA in samples from leprosy patients are included in the diagnosis of leprosy, the study of drug resistance and the epidemiological investigation. Recently, application of the polymerase chain reaction to epidemiological study of leprosy is introduced. PCR-based typing would be of great value for epidemiological investigation; to identify infectious source of leprosy, understand transmission pattern, and distinguish between relapse & re-infection. Variable TTC DNA repeats in non-coding region and 6bp(ACATCG) tandem repeats in rpoT gene revealed PCR products of different size may be useful to investigate the epidemiology of leprosy.

Keyword

Epidemiology; Leprosy; Mycobacterium leprae; genotyping; PCR
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