- Possibility of Zebrafish as New infection model for Leprosy
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Kim JP, Choi HY, Cho SN
- KMID: 1512597
- Korean Lepr Bull.
- 2006 Jun;39(1):37-48.
The zebrafish emerged as a new model of developmental research and infection. Recently zebrafish were used for various mycobacterial infection studies. In this study, we investigated a possibility of the... -
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- Drug resistance in Mycobacterium leprae
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Kashivabara Y
- KMID: 1883232
- Korean Lepr Bull.
- 1999 Dec;32(2):1-4.
No abstract available. -
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- The association study on infection of Mycobacterium leprae and RIPK2
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Kim BC, Kang TJ, Chae GT
- KMID: 1921046
- Korean Lepr Bull.
- 2003 Dec;36(2):23-29.
Receptor-interacting serine/threonine kinase 2(RIPK2) is an adaptor molecule involved in the signal pathway of TLRs. However, there is no report on association between RIPK2 expression and infectious disease including... -
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- VNTR typing studies of Mycobacterium lepare in Korea
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Kim JP
- KMID: 2308480
- Korean Lepr Bull.
- 2011 Dec;44(1):9-25.
Leprosy is a chronic disease caused by Mycobacterium leprae and is characterized by disfiguring bacterial inclusions in the skin, peripheral nerves, and respiratory mucosa. Despite the success of multidrug therapy,... -
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- Mycobacterium Leprae in Cultured Mouse Peritoneal Macrophages: In vivo Infection In vitro Cultivation
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Yang YT, Lew J
- KMID: 687652
- Yonsei Med J.
- 1971 Dec;12(1):1-12.
- doi: 10.3349/ymj.1971.12.1.1
To grow Mycobacterium leprae in cultured mouse peritoneal macrophages, studies were made on 1) the purification of M. leprae from lepromatous nodules by trypsinization, 2) growth experiment of purified M.... -
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- Effects of Mycobacterium leprae , M . leprae Phenolic Glycolipid - 1 and Cytokines on the Nitric Oxide Generation of RAW 264 . 7 Macrophages
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Park SD, Lee JS, Lee BS, Jun CD, Chung HT, Kim JG
- KMID: 2230814
- Korean J Dermatol.
- 1994 Apr;32(2):234-244.
Background: Nitric oxide(NO) has been reproted to play an important role in macrophage-mediated microbicidal capacity for a variety of intracellular pathogens. NO generation is used as an indicator of microbicidal... -
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- Effect of temperature and medium on the viability of Mycobacterium leprae during long term-storage
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Park JH, Kim YJ, Kim JP
- KMID: 2466491
- Korean Lepr Bull.
- 2019 Dec;52(1):41-50.
- doi: 10.33161/klb.2019.52.1.41
BACKGROUND: Mycobacterium leprae (M. leprae) is pathogenic bacterium with polymorphic, acid-fast properties and causes leprosy that it is called Hansen's disease. Leprosy can be completely cured using multidrug therapy (MDT),... -
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- The role of mycobacterial katG gene in activation of isoniazid
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Kang TJ, Chae GT
- KMID: 1584950
- Korean Lepr Bull.
- 2000 Dec;33(2):55-66.
Since Mycobacterium leprae, the causative organism of Leprosy, proliferate inside macrophages, it has been speculated that catalase encoded by the katG gene may protect acid-fast bacilli from the deleterious effects... -
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- Detection of Mycobacterium leprae in Tissue and Blood by Polymerase Chain Reaction
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Lee KS, Oh KY, Ryoo YW, Suh MH, Song JY
- KMID: 2361448
- Ann Dermatol.
- 1994 Jul;6(2):130-135.
- doi: 10.5021/ad.1994.6.2.130
BACKGROUND: Methods to detect and quanitify Mycobacterium leprae(M. leprae)are needed for studies involving the epidemiology, pathogenesis, and chemotherapy of leprosy. Serological assays and skin tests lack the sensitivity and specificity... -
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- SNP Genotypes of Mycobacterium leprae Isolated in Korea
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Kim JP
- KMID: 1765914
- Korean Lepr Bull.
- 2012 Dec;45(1):3-19.
Leprosy is an important health problem worldwide yet. It is caused by a chronic granulomatous infection of the skin and peripheral nerves with Mycobacterium leprae. The clinical findings from tuberculoid... -
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- Expression of Nucleotide-oligomerization Domain (NOD) and Related Genes in Mouse Tissues Infected with Mycobacterium leprae
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Kim TH, Chae GT, Kang TJ
- KMID: 2132706
- Immune Netw.
- 2015 Dec;15(6):319-324.
- doi: 10.4110/in.2015.15.6.319
The nucleotide-oligomerization domain (NOD) is an important molecule involved in host defense against bacterial infection. To study the role of NODs in the host response to Mycobacterium leprae, we measured... -
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- The upstream sequence of Mycobacterium leprae 18-kDa gene confers transcription repression activity in orientation-independent manner
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Kim HB, You JC
- KMID: 1103317
- Exp Mol Med.
- 2004 Dec;36(6):510-514.
In order to understand the role of the upstream region of the Mycobacterium leprae 18-kDa gene on the gene regulation, the region was divided into two at the -50 position... -
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- Seroactivities to Phenolic Glycolipid I of Mycobacterium leprae Among Leprosy Patients in National sorokdo Hospital and Their Children
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Hwang KK, Cho SN
- KMID: 2038963
- Korean J Dermatol.
- 1988 Aug;26(4):513-517.
Using ELlSA, 83 sera from leprosy patients in National Sorokdo Hospital who are clessified bacteriologically positive and 40 sera from patient's children were tested for a.ntibedy to phenolic glycolipid I... -
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- Rapid detection of Mycobacterium leprae for the diagnosis of leprosy: comparison between loop-mediated isothermal amplification and PCR.
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Kim JP, Ko YH
- KMID: 1598599
- Korean Lepr Bull.
- 2005 Jun;38(1):25-34.
Loop-mediated isothermal amplification (LAMP) is a novel nucleic acid amplification method that amplifies DNA with high specificity, efficiency, and speed under isothermal conditions. To evaluate the usefulness of LAMP for... -
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- Prevalence of IgM antibodies to phenolic glycolipid I of Mycobacterium leprae among controls, workers and foreigners in Korea
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Kim JP, Kim YS, Cho SN, Ko YH
- KMID: 1910888
- Korean Lepr Bull.
- 2004 Dec;37(2):19-27.
Phenolic glycolipid I (PGL-I) is a Mycobacterium leprae-specific antigen, and the antibodies to the antigen may suggest an M. leprae infection. To compare the M. leprae infection among the populations,... -
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- Molecular Epidemiology of Mycobacterium leprae as Determined by Structure-Neighbor Clustering in Korea found cases
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Kim JP
- KMID: 2405549
- Korean Lepr Bull.
- 2017 Dec;50(1):25-42.
- doi: 10.0000/klb.2017.50.1.25
BACKGROUND: It has proven challenging to investigate the molecular epidemiology of Mycobacterium leprae, the causative agent of leprosy, due to difficulties with culturing of the organism and a lack of... -
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- Heterologous Regulation of BCG hsp65 Promoter by M. leprae 18 kDa Transcription Repression Responsive Element
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Kim HB, You JC
- KMID: 2053075
- Genomics Inform.
- 2003 Dec;1(2):113-118.
Among a number of antigens characterized in M. leprae, an etiological agent of Leprosy, the 18 kDa antigen, is unique to M. leprae. We have previously determined a sequence specific... -
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- Atypical Papulonecrotic Skin Manifestation by Lepromatous Leprosy
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Park JH, Kim SJ, Lee SC, Won YH, Chun IK
- KMID: 2360404
- Ann Dermatol.
- 1997 Apr;9(2):143-146.
- doi: 10.5021/ad.1997.9.2.143
Leprosy is a multisystemic infectious disease showing various cutaneous manifestations by the reaction between Mycobacterium leprae (M. leprae) and host immunity. We de-scribe a 20-year-old woman with clinical multiple papulonecrotic... -
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- Identification of regulatory sequence within the promoter of M.leprae-specific 18-kDa gene and its binding factor(s)
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Kim MJ, Kim YK, Chae GT
- KMID: 2139281
- Korean Lepr Bull.
- 2000 Jun;33(1):107-113.
A central question to the pathogenesis of leprosy is how Mycobacterium leprae, the causative agent of leprosy, survives and replicates within macrophages. 18-kDa protein of M. leprae, a major antigen,... -
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- Detection of Mycobacterium leprae in Skin Biopsy Sepcimens From Leprosy patients by Polymerase Chain Reaction
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Yoon KH, Cho SN, Lee JB, Kim JD
- KMID: 1681207
- Korean J Dermatol.
- 1994 Jun;32(3):409-415.
BACKGROUND: Polymerase chain reaction(PCR) has brought an oppotunity for rapid detection of Mycobacterium leprae in clinical pecimens for the diagnosis of leprosy. Th DNA segment specific to M. leprae was... -
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