Korean J Anat.  2002 Aug;35(4):355-361.

Apolipoprotein E Polymorphism in Ischemic and Hemorrhagic Stroke

• Yi HA
• Lim JG
• Kwon OD
• Cho YW
• Lee H
• Yi SD
• Kim DK

Abstract

There is an evidence for a role of apolipoprotein E (APOE) in atherosclerosis, coronary heart disease and carotid artery stenosis. Morbidity of carotid artery atherosclerosis is higher in persons carrying an epsilon4 allele, but the association of cerebrovascular disease and apoE genotype is controversial. We studied the association between APOE genotype and allele (epsilon2, epsilon3, epsilon4) frequency and stroke. We evaluated APOE genotype in 133 first -ever stroke patients and 111 healthy controls. We also estimated the risk factors of stroke such as hypertension, diabetes and lipid profiles in both groups. APOE genotypes were analyzed by polymerase chain reaction. APOE genotypes and allele distributions were not different in patients and controls. There is also no difference of APOE allele frequencies between ischemic small artery occlusive disease and hypertensive subcortical intracerebral hemorrhage. We concluded that the APOE -epsilon4 allele is not associated with stoke including ischemic and hemorrhagic stroke.

Keyword

Apo E allele; Polymorphism; Ischemic stroke; Hemorrhagic stroke

MeSH Terms

Alleles
Apolipoproteins E
Apolipoproteins*
Arteries
Atherosclerosis
Carotid Arteries
Carotid Stenosis
Cerebral Hemorrhage
Coronary Artery Disease
Gene Frequency
Genotype
Heart Diseases
Humans
Hypertension
Polymerase Chain Reaction
Risk Factors
Stroke*
Apolipoproteins
Apolipoproteins E