Hanyang Med Rev.  2006 Aug;26(3):9-17.

Pediatric Liver Transplantation

Affiliations
  • 1Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Korea. sklee@smc.samsung.co.kr

Abstract

Since the past several decades, remarkable improvements in the management of pediatric liver transplantation was achieved and pediatric transplant surgeons have transformed a once hopeless end-stage liver disease in children into a treatable disease with limited mortality. Biliary atresia, the most common indication of liver transplantation, needs judicious selection of patients and timing of transplantation in order to achieve best results. In fulminant hepatic failure, laboratory data and neurological signs help decide the need for transplantation and determine the prognosis. Various types of transplantation methods are possible, but the living donor liver transplantation using the left lateral section is currently the most widely used. Therapeutic interventions, such as percutaneous transhepatic biliary drainage or balloon angioplasty can be used to manage post-transplant complications with minimal morbidity. Vigilant prophylaxis against viral infections with careful use of balanced immunosuppressive medications can prevent deleterious diseases such as cytomegalovirus infection or post-transplant lymphoproliferative disease. Despite the improved results, more study needs to be done to elucidate the long-term outcome of these young liver recipients.

Keyword

Liver transplantation; Pediatric; Biliary atresia; Indication; Complication

MeSH Terms

Angioplasty, Balloon
Biliary Atresia
Child
Cytomegalovirus Infections
Drainage
Humans
Liver Diseases
Liver Failure, Acute
Liver Transplantation*
Liver*
Living Donors
Mortality
Prognosis
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