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New in vitro multiple cardiac ion channel screening system for preclinical Torsades de Pointes risk prediction under the Comprehensive in vitro Proarrhythmia Assay concepta

An JR, Mun SY, Jung IK, Kim KS, Kwon CH, Choi SO, Park WS

Cardiotoxicity, particularly drug-induced Torsades de Pointes (TdP), is a concern in drug safety assessment. The recent establishment of human induced pluripotent stem cell-derived cardiomyocytes (human iPSC-CMs) has become an attractive...
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Elevated On-Treatment Diastolic Blood Pressure and Cardiovascular Outcomes in the Presence of Achieved Systolic Blood Pressure Targets

Kim DH, Cho IJ, Kim W, Lee CJ, Kim HC, Shin JH, Kang SH, Jung MH, Kwon CH, Lee JH, Kim HL, Kim HM, Cho I, Kang DR, Lee HY, Chung WJ, Kim KI, Cho EJ, Sohn IS, Park S, Shin J, Ryu SK, Kang SM, Pyun WB, Cho MC, Kim JH, Lee JH, Ihm SH, Sung KC

Background and Objectives: This study aimed to investigate the association between cardiovascular events and 2 different levels of elevated on-treatment diastolic blood pressures (DBP) in the presence of achieved systolic...
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Whole-Exome Sequencing in Papillary Microcarcinoma: Potential Early Biomarkers of Lateral Lymph Node Metastasis

Kim M, Kwon CH, Jang MH, Kim JM, Kim EH, Jeon YK, Kim SS, Choi KU, Kim IJ, Park M, Kim BH

Background: Early identification of patients with high-risk papillary thyroid microcarcinoma (PTMC) that is likely to progress has become a critical challenge. We aimed to identify somatic mutations associated with lateral...
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Clinical Significance of TWIST-Positive Circulating Tumor Cells in Patients with Esophageal Squamous Cell Carcinoma

Lee HJ, Kim GH, Park SJ, Kwon CH, Lee MW, Lee BE, Baek DH, I H

Background/Aims: Unlike other gastrointestinal tract cancers, there are relatively few reports on the clinical significance of circulating tumor cells (CTCs) and TWIST, a marker of epithelial-mesenchymal transition, in patients with...
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Extensive Deep Vein Thrombosis after Electrophysiology Study

Kwon CH

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External Electrical Cardioversion is an Easy and Safe Intervention for Rhythm Control in Persistent Atrial Fibrillation

Kwon CH

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Efficacy and safety of prolonged-release versus immediate-release tacrolimus in de novo liver transplant recipients in South Korea: a randomized open-label phase 4 study (MAPLE)

Kim MS, Joh JW, Kim DS, Kim SH, Choi JS, Lee J, Lee JY, Kim JM, Kwon CH, Choi GS, Yu YD, Yoon YI, Han JH, Lee YJ, Jiang H, Kim SI

BACKGROUND: Prolonged-release tacrolimus is associated with better long-term graft and patient survival than the immediate-release formulation in liver transplant patients. However, no clinical data are available to assess the efficacy...
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Impact of technical innovation on surgical outcome of laparoscopic major liver resection: 10 years' experience at a large-volume center

Cho W, Kwon CH, Choi JY, Lee SH, Kim JM, Choi GS, Joh JW, Kim SJ, Kim GS, Koh KC

PURPOSE: Laparoscopic major liver resection (major LLR) remains a challenging procedure because of the technical difficulty. Several significant technical innovations have been applied in our center since 2012. They include...
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Long-term outcomes after stent insertion in patients with early and late hepatic vein outflow obstruction after living donor liver transplantation

Kim KS, Lee JS, Choi GS, Kwon CH, Cho JW, Lee SK, Park KB, Cho SK, Shin SW, Kim JM

PURPOSE: The purpose of this study was to describe the long-term effects of stenting in patients with hepatic venous outflow obstruction (HVOO), who underwent living donor liver transplantation (LDLT). METHODS: Between...
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Laparoscopy of hepatocellular carcinoma is helpful in minimizing intra-abdominal adhesion during salvage transplantation

Rhu J, Kim JM, Choi GS, Kwon CH, Joh JW, Soubrane O

PURPOSE: This study analyzes the impact of laparoscopic liver resection on intra-abdominal adhesion. METHODS: Patients who underwent salvage liver transplantation after liver resection for hepatocellular carcinoma from January 2012 to October...
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Continuing five or more locoregional therapies before living donor salvage liver transplantation for hepatocellular carcinoma is related to poor recurrence-free survival

Rhu J, Kim JM, Choi GS, Kwon CH, Joh JW

PURPOSE: This study was designed to analyze factors related to the success of salvage liver transplantation (SLT) in hepatocellular carcinoma (HCC). While liver resection (LR) is considered the best locoregional...
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Use of direct antiviral agents in liver transplant recipients with hepatitis C virus in Korea: 2-center experience

Kim JM, Lee KW, Sinn DH, Choi GS, Yi NJ, Kwon CH, Suh KS, Joh JW

PURPOSE: The proportion of liver recipients with HCV is gradually increasing in Korea. Limited data are available regarding the efficacy of direct antiviral agents (DAAs) in liver transplant recipients in...
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Clinical usefulness of transarterial chemoembolization response prior to liver transplantation as predictor of optimal timing for living donor liver transplantation

Cho CW, Choi GS, Kim JM, Kwon CH, Kim DJ, Joh JW

PURPOSE: Response to preoperative transarterial chemoembolization (TACE) has been recommended as a biological selection criterion for liver transplantation (LT). The aim of our study was to identify optimal timing of...
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Living donor liver transplantation prior to multiple myeloma treatment in a patient with hepatitis B-associated hepatocellular carcinoma and liver cirrhosis: a case report

Cho CW, Lee N, Choi GS, Kim JM, Kwon CH, Joh JW

Clinical outcomes of living donor liver transplantation (LDLT) for hepatocellular carcinoma (HCC) in patients with multiple myeloma (MM) have not been established in terms of HCC recurrence and MM deterioration...
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Prognosis of preoperative positron emission tomography uptake in hepatectomy patients

Kim JM, Kwon CH, Joh JW, Sinn DH, Choi GS, Paik SW

PURPOSE: Preoperative F-18-fluoro-2-deoxy-glucose positron emission tomography (18F-FDG PET) imaging results appear to predict tumor recurrence and patient survival. The present study compared outcomes between PET-positive and PET-negative groups with HBV-related...
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Comparison Study of Outcomes of Deceased Donor Liver Transplantation before and after Korean Model for End-Stage Liver Disease (MELD) System: Single Center Experience

Lee JA, Choi GS, Kim JM, Kwon CH, Joh JW

BACKGROUND: In June of 2016, the Model for End-Stage Liver Disease (MELD)-based allocation system replaced the Child-Turcotte-Pugh (CTP) score-based system for deceased donor liver transplantation (DDLT) in Korea. This study...
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Bacterial infection monitoring in the early period after liver transplantation

Lee JS, Lee SH, Kim KS, Gil EM, Choi GS, Kim JM, Peck KR, Kwon CH, Joh JW, Lee SK

PURPOSE: Infection remains the main cause of morbidity and mortality in liver transplantation (LT) recipients; however infection is notoriously difficult to diagnose because its usual signs and symptoms of infection...
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Early disseminated recurrence after liver resection in solitary hepatocellular carcinoma

Kim JM, Yi NJ, Kwon CH, Lee KW, Suh KS, Joh JW

PURPOSE: Although few hepatectomy patients develop unexpected early diffuse and multinodular recurrence in the remnant liver, the prognosis in such cases is often dismal. The aim of this study was...
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Increased survival in hepatitis c patients who underwent living donor liver transplant: a case-control study with propensity score matching

Kim JM, Lee KW, Song GW, Jung BH, Lee HW, Yi NJ, Kwon CH, Hwang S, Suh KS, Joh JW, Lee SK, Lee SG

PURPOSE: There is no consensus regarding the difference in outcomes of HCV in patients who receive living donor liver transplantation (LDLT) or compared to deceased donor liver transplantation (DDLT). The...
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Extracorporeal membrane oxygenation support for refractory septic shock in liver transplantation recipients

Lee KW, Cho CW, Lee N, Choi GS, Cho YH, Kim JM, Kwon CH, Joh JW

PURPOSE: This study was designed to assess the outcome of the extracorporeal membrane oxygenation (ECMO) in liver transplantation (LT) recipients with refractory septic shock and predict the prognosis of those...
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