J Korean Surg Soc.  2009 Oct;77(4):246-249. 10.4174/jkss.2009.77.4.246.

Analysis of Clinicopathologic Features in Papillary Thyroid Carcinoma Patients Younger than Thirty

Affiliations
  • 1Department of Surgery, Kwangju Christian Hospital, Gwangju, Korea. cumo94@hanmail.net

Abstract

PURPOSE
This study analyzed clinicopathologic features in patients with thyroid papillary carcinoma, who were younger than thirty, compared with patients aged thirty and forty-five. METHODS: The clinical records of 337 patients who underwent thyroidectomy because of papillary thyroid carcinoma were reviewed. Among them, 62 patients who were younger than thirty were placed in group I. And 275 patients between thirty and forty-five were placed in to group II. Clinicopathologic features between the two groups were analyzed. RESULTS: There was no significant difference between two groups in age, gender, tumor extension, and multifocality. Symptoms before detection of papillary thyroid carcinoma such as palpable mass, compressive symptoms or hoarseness were significantly higher in group I (P=0.008). In tumor size, rate of microcarcinoma is significantly higher in group II (P=0.024). Lymph node metastasis was found to be more significant in group I (P=0.010). The operative methods were different between the two groups. Rate of total thyroidectomy was increased in group I (P=0.021). CONCLUSION: This study shows that patients with thyroid papillary carcinoma, younger than thirty have more clinical symptoms and more large sized masses, more lymph node metastases at the time of surgery compared with those aged between thirty and forty-five.

Keyword

Papillary thyroid carcinoma; Clinicopathologic feature; Thirty

MeSH Terms

Aged
Carcinoma
Carcinoma, Papillary
Hoarseness
Humans
Lymph Nodes
Neoplasm Metastasis
Thyroid Gland
Thyroid Neoplasms
Thyroidectomy
Carcinoma
Thyroid Neoplasms

Reference

1. Shin SH, Na MA, Kang YH, Son SM, Kim IJ, Kim YK. The histological features of papillary thyroid carcinomas 1.5 cm and less in size. Korean J Med. 2007. 73:44–49.
2. Ministry of Health and Welfare. 2002 Annual Report of the Korea Central Cancer Registry. 2003.
3. Akslen LA, LiVolsi VA. Prognostic significance of histologic grading compared with subclassification of papillary thyroid carcinoma. Cancer. 2000. 88:1902–1908.
4. Yamashita H, Noguchi S, Murakami N, Toda M, Uchino S, Watanabe S, et al. Extracapsular invasion of lymph node metastasis. A good indicator of disease recurrence and poor prognosis in patients with thyroid microcarcinoma. Cancer. 1999. 86:842–849.
5. Hedinger CE, Williams ED, Sobin LH. Histological Typing of Thyroid Tumors. WHO International Histological Classification of Tumors. 1988. 2nd ed. Berlin: Springer-Verlag.
6. Pitman MB, Abele J, Ali SZ, Duick D, Elsheikh TM, Jeffrey RB, et al. Techniques for thyroid FNA: a synopsis of the National Cancer Institute Thyroid Fine-Needle Aspiration State of the Science Conference. Diagn Cytopathol. 2008. 36:407–424.
7. Gharib H. Current evaluation of thyroid nodules. Trends Endocrinol Metab. 1994. 5:365–369.
8. Mazzaferri EL. Management of a solitary thyroid nodule. N Engl J Med. 1993. 328:553–559.
9. McConahey WM, Hay ID, Woolner LB, van Heerden JA, Taylor WF. Papillary thyroid cancer treated at the Mayo Clinic, 1946 through 1970: initial manifestations, pathologic findings, therapy, and outcome. Mayo Clin Proc. 1986. 61:978–996.
10. Hay ID, Grant CS, Bergstralh EJ, Thompson GB, van Heerden JA, Goellner JR. Unilateral total lobectomy: is it sufficient surgical treatment for patients with AMES low-risk papillary thyroid carcinoma? Surgery. 1998. 124:958–964.
11. Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, et al. Management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 2006. 16:109–142.
12. Grebe SK, Hay ID. Thyroid cancer nodal metastases: biologic significance and therapeutic considerations. Surg Oncol Clin N Am. 1996. 5:43–63.
13. Lee J, Yun JS, Nam KH, Chung WY, Soh EY, Park CS. Papillary thyroid microcarcinoma: clinicopathologic characteristics and treatment strategy. J Korean Surg Soc. 2007. 72:276–282.
14. Marchesi M, Biffoni M, Faloci C, Biancari F, Campana FP. High rate of recurrence after lobectomy for solitary thyroid nodule. Eur J Surg. 2002. 168:397–400.
15. Hazard JB. Small papillary carcinoma of the thyroid. A study with special reference to so-called nonencapsulated sclerosing tumor. Lab Invest. 1960. 9:86–97.
16. Farkas EA, King TA, Bolton JS, Fuhrman GM. A comparison of total thyroidectomy and lobectomy in the treatment of dominant thyroid nodules. Am Surg. 2002. 68:678–682.
17. Chow SM, Law SC, Chan JK, Au SK, Yau S, Lau WH. Papillary microcarcinoma of the thyroid-Prognostic significance of lymph node metastasis and multifocality. Cancer. 2003. 98:31–40.
18. Shaha A. Treatment of thyroid cancer based on risk groups. J Surg Oncol. 2006. 94:683–691.
19. Shah JP, Loree TR, Dharker D, Strong EW. Lobectomy versus total thyroidectomy for differentiated carcinoma of the thyroid: a matched-pair analysis. Am J Surg. 1993. 166:331–335.
20. Lim SW, Park SJ, Cho HJ, Gwak GH, Yang KH, Bae BN, et al. Analysis of factors affecting local recurrences after thyroid surgery in low risk papillary thyroid carcinomas. Korean J Endocrine Surg. 2008. 8:118–122.
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