Int J Oral Biol.  2010 Dec;35(4):145-151.

Protective Effect of HP08-0111 on Ligature-Induced Periodontitis

• Park YR
• Cho HK
• Soh Y

Abstract

Periodontitis is an inflammatory disorder of the periodontium and is characterized by destruction of the tooth supporting tissues, mediated by the upregulation of synthesis and release of a variety of pro-inflammatory factors. Inflammatory cytokines and prostaglandins upregulate RANKL and its subsequent binding to RANK stimulates osteoclast formation, resorption activity, and survival. In our present study, we investigated the effects of HP08-0111, composed of Coptis japonica (Thunb.) Makino, vitamin C and vitamin E, upon inflammatory responses, osteoclastogenesis and alveolar bone loss. HP08-0111 decreased the expression of IL-1beta and COX2 on LPS-induced RAW 264.7 cells and inhibited osteoclast-specific genes such as c-Fos, MMP-9, and TRAP. HP08-0111 also exhibited protective effects against alveolar bone loss in rats with ligature-induced periodontitis. Our results suggest that HP08-0111 is potentially an important therapeutic tool for the treatment of disorders associated with bone loss such as periodontitis.

Keyword

HP08-0111; periodontitis; anti-inflammatory; osteoclastogenesis

MeSH Terms

Alveolar Bone Loss
Animals
Ascorbic Acid
Coptis
Cytokines
Osteoclasts
Periodontitis
Periodontium
Prostaglandins
Rats
Tooth
Up-Regulation
Vitamin E
Vitamins
Ascorbic Acid
Cytokines
Prostaglandins
Vitamin E
Vitamins