J Korean Soc Transplant.  2011 Sep;25(3):165-168. 10.4285/jkstn.2011.25.3.165.

Issues on Long-term Management after Liver Transplantation in Children

  • 1Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea. kmkim@amc.seoul.kr


With advancements of liver transplantation, the patient's survival improved remarkably. Thus the long-term survivors are increasing especially for the pediatric liver transplantation recipients. Consequently they are facing the challenge of maintaining graft function while minimizing long-term complications. In this review, I will discuss calcineurin inhibitor toxicity, problems with steroid, adherence to medical regimen, posttransplant growth, chronic graft dysfunction, tolerance.


Child; Liver transplantation; Postoperative complications; Medication adherence; Transplantation tolerance

MeSH Terms

Liver Transplantation
Medication Adherence
Postoperative Complications
Transplantation Tolerance


  • Fig. 1. The overall rates of patient survival at two time period. Those before 2003 at 1 and 5 years were 86.4%, 79.5%, and 78.4%, respectively. Those after 2003 were 95.4% and 95.4%, respectively (P<0.05, Kaplan-Meier method). There is a statistically significant improvement in patient survival. Reprinted from reference [2].

  • Fig. 2. Post-transplantation height mean standard deviation scores (zH) of children with retarded growth (●) and normal growth (■) at time of transplantation. The height of growth-re-tarded children was restored by catch-up growth and non-growth-retarded children grew adequately for up to 7 years. Adapted from reference [13].



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